《毒物学科学杂志》.2005年.第2期
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- Xenobiotics Inhibit Hepatic Uptake and Biliary Excretion of Taurocholate in Rat Hepatocytes
- A Toxicogenomic Approach to Drug-Induced Phospholipidosis: Analysis of Its Induction Mechanism and Establishment of a Novel in Vitro Screeni
- Stabilization of Nrf2 by tBHQ Confers Protection against Oxidative Stress-Induced Cell Death in Human Neural Stem Cells
- Albumin, a New Biomarker of Organophosphorus Toxicant Exposure, Identified by Mass Spectrometry
- Chaperone Proteins Involved in Troglitazone-Induced Toxicity in Human Hepatoma Cell Lines
- Induction of Cell-Cycle Arrest by all-trans Retinoic Acid in Mouse Embryonic Palatal Mesenchymal(MEPM) Cells
- Aryl Hydrocarbon Receptor Expression and Activity in Cerebellar Granule Neuroblasts: Implications for Development and Dioxin Neurotoxicity
- Aluminum-Maltolate Induces Apoptosis and Necrosis in Neuro-2a Cells: Potential Role for p53 Signaling
- Acute Respiratory Responses of the Mouse to Chlorine
- Downregulation of Lysyl Oxidase and Upregulation of Cellular Thiols in Rat Fetal Lung Fibroblasts Treated with Cigarette Smoke Condensate
- Early Developmental 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Exposure Decreases Chick Embryo Heart Chronotropic Response to Isoproterenol but Not
- Methoxychlor Induces Proliferation of the Mouse Ovarian Surface Epithelium
- 2,2',4,6,6'-Pentachlorobiphenyl-Induced Apoptosis Is Limited by Cyclooxygenase-2 Induction
- Acute Hemorrhagic Myocardial Necrosis and Sudden Death of Rats Exposed to a Combination of Ephedrine and Caffeine
- Toxicokinetics of BDE 47 in Female Mice: Effect of Dose, Route of Exposure, and Time
- Deregulation of Cell Proliferation by Polycyclic Aromatic Hydrocarbons in Human Breast Carcinoma MCF-7 Cells Reflects Both Genotoxic and Non
- Effects of Co-administration of Antioxidants and Arsenicals on the Rat Urinary Bladder Epithelium
- On the Importance of Exposure Variability to the Doses of Volatile Organic Compounds
- Development of an Oral Exposure Mouse Model to Predict Drug-Induced Hypersensitivity Reactions by Using Reporter Antigens
- Interaction of Polycyclic Musks and UV Filters with the Estrogen Receptor(ER), Androgen Receptor(AR), and Progesterone Receptor(PR) in Re
- Co-culture of Primary Human Mammary Fibroblasts and MCF-7 Cells as an In Vitro Breast Cancer Model
- Toxicokinetics and Oral Bioavailability of Halogenated Acetic Acids Mixtures in Nave and GSTzeta-Depleted Rats
- Effects of Di-(2-Ethylhexyl)-Phthalate(DEHP) and Its Metabolites on Fatty Acid Homeostasis Regulating Proteins in Rat Placental HRP-1 Troph
- Effects of 2,2',4,4'-Tetrachlorobiphenyl on Granulocytic HL-60 Cell Function and Expression of Cyclooxygenase-2
- Bisphenol A Accelerates Terminal Differentiation of 3T3-L1 Cells into Adipocytes through the Phosphatidylinositol 3-Kinase Pathway
- Activation of Mitogen Activated Protein Kinases by PCB126(3,3',4,4',5-Pentachlorobiphenyl) in HepG2 Cells
- Mycotoxin Fumonisin B1 Alters the Cytokine Profile and Decreases the Vaccinal Antibody Titer in Pigs
- Effects of Repeated Oral Postnatal Exposure to Chlorpyrifos on Cholinergic Neurochemistry in Developing Rats
- Inorganic Arsenic Compounds and Methylated Metabolites Induce Morphological Transformation in Two-Stage BALB/c 3T3 Cell Assay and Inhibit Me
- A Mechanistic Basis for the Role of Cycle Arrest in the Genetic Toxicology of the Dietary Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]
- Inhibition of Human and Rat CYP1A2 by TCDD and Dioxin-like Chemicals
- Essential Role of Extracellular Matrix(ECM) Overlay in Establishing the Functional Integrity of Primary Neonatal Rat Sertoli Cell/Gonocyte
- Heart Malformation Is an Early Response to TCDD in Embryonic Zebrafish
- Neuroanatomical Targets of the Organophosphate Chlorpyrifos by c-fos Immunolabeling
- Increased Hepatobiliary Clearance of Unconjugated Thyroxine Determines DMP 904-Induced Alterations in Thyroid Hormone Homeostasis in Rats
- Acute Inflammatory Responses to Stachybotrys chartarum in the Lungs of Infant Rats: Time Course and Possible Mechanisms
- Subchronic Exposure to Low Concentrations of Di-n-Butyl Phthalate Disrupts Spermatogenesis in Xenopus laevis Frogs
- Ah Receptor-Mediated Impairment of Interrenal Steroidogenesis Involves StAR Protein and P450scc Gene Attenuation in Rainbow Trout
- Comparative Study of the Endocrine-Disrupting Activity of Bisphenol A and 19 Related Compounds
- Induction of Colon Tumors in C57BL/6J Mice Fed MeIQx, IQ, or PhIP Followed by Dextran Sulfate Sodium Treatment
- Sodium Arsenite Exposure Alters Cell Migration, Focal Adhesion Localization and Decreases Tyrosine Phosphorylation of Focal Adhesion Kinase
- Estrogen Receptor Pathway Is Involved in the Regulation of Calbindin-D9k in the Uterus of Immature Rats
- Ribotoxic Stress Response to the Trichothecene Deoxynivalenol in the Macrophage Involves the Src Family Kinase Hck
- Post-Transcriptional Regulation of Metallothionein Isoform 1 and 2 Expression in the Human Breast and the MCF-10A Cell Line
- Metabonomics in Toxicology: A Review
- Acute Cardiopulmonary Alterations Induced by Fine Particulate Matter of So Paulo, Brazil
- Long-Term Neurotoxicity of Chlorpyrifos: Spatial Learning Impairment on Repeated Acquisition in a Water Maze
- Identification of the Tryptophan Photoproduct 6-Formylindolo[3,2-b]carbazole, in Cell Culture Medium, as a Factor That Controls the Backgrou
- Characterization of Chemically Induced Hepatotoxicity in Collagen Sandwiches of Rat Hepatocytes
- CO Inhalation at Dose Corresponding to Tobacco Smoke Worsens Cardiac Remodeling after Experimental Myocardial Infarction in Rats
- Differential Effects of Commercial Polybrominated Diphenyl Ether and Polychlorinated Biphenyl Mixtures on Intracellular Signaling in Rat Bra
- The Effects of Early Lead Exposure on the Brains of Adult Rhesus Monkeys: A Volumetric MRI Study
- Effects of In Utero and Lactational TCDD Exposure on Bone Development in Differentially Sensitive Rat Lines
- Evaluation of Oral and Intravenous Route Pharmacokinetics, Plasma Protein Binding, and Uterine Tissue Dose Metrics of Bisphenol A: A Physiol
- Diesel Exhaust Enhances Influenza Virus Infections in Respiratory Epithelial Cells
- The Rat Ear Vein Model for Investigating In Vivo Thrombogenicity of Ultrafine Particles(UFP)
- A Comparison of Ratio Distributions Based on the NOAEL and the Benchmark Approach for Subchronic-to-Chronic Extrapolation
- Changes in Androgen-Mediated Reproductive Development in Male Rat Offspring Following Exposure to a Single Oral Dose of Flutamide at Differe
- Activator Protein-1(AP-1) DNA Binding Activity Is Induced by Hydroxyurea in Organogenesis Stage Mouse Embryos
- Identification of a Rapid Detoxification Mechanism for Brevetoxin in Rats
- Temporal and Dose-Dependent Hepatic Gene Expression Patterns in Mice Provide New Insights into TCDD-Mediated Hepatotoxicity
- Miotic Tolerance to Sarin Vapor Exposure: Role of the Sympathetic and Parasympathetic Nervous Systems
- DNA Interaction and Dual Topoisomerase I and II Inhibition Properties of the Anti-Tumor Drug Prodigiosin
- The Glycolytic Enzyme Glyceraldehyde-3-Phosphate Dehydrogenase Works as an Arsenate Reductase in Human Red Blood Cells and Rat Liver Cytosol
- Reduction of Arsenate to Arsenite by Human Erythrocyte Lysate and Rat Liver Cytosol – Characterization of a Glutathione- and NAD-Dependent A
- Perinatal Exposure to the Fungicide Prochloraz Feminizes the Male Rat Offspring
- Manganese Acts Centrally to Stimulate Luteinizing Hormone Secretion: A Potential Influence on Female Pubertal Development
- Protein Adduct Formation as a Molecular Mechanism in Neurotoxicity
- Di-n-Butyl Phthalate Activates Constitutive Androstane Receptor and Pregnane X Receptor and Enhances the Expression of Steroid-Metabolizing
- The Tobacco Alkaloid Nicotine Demonstrates Genotoxicity in Human Tonsillar Tissue and Lymphocytes
- Effects of Two Fungicides with Multiple Modes of Action on Reproductive Endocrine Function in the Fathead Minnow(Pimephales promelas)
- Blood Acylpeptide Hydrolase Activity Is a Sensitive Marker for Exposure to Some Organophosphate Toxicants
- Comparative Microarray Analysis of Basal Gene Expression in Mouse Hepa-1c1c7 Wild-Type and Mutant Cell Lines
- The Effect of the Food Matrix on In Vivo Immune Responses to Purified Peanut Allergens
- Different Types of Combination Effects for the Induction of Micronuclei in Mouse Lymphoma Cells by Binary Mixtures of the Genotoxic Agents M
- Chronic Developmental Lead Exposure Reduces Neurogenesis in Adult Rat Hippocampus but Does Not Impair Spatial Learning
- Neurobehavioral Effects of Chronic Dietary and Repeated High-Level Spike Exposure to Chlorpyrifos in Rats
- Nrf2 Activation Involves an Oxidative-Stress Independent Pathway in Tetrafluoroethylcysteine-Induced Cytotoxicity
- Gene Expression Changes Induced in the Testis by Transplacental Exposure to High and Low Doses of 17-Ethynyl Estradiol, Genistein, or Bisphe
- In Utero and Lactational 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure: Effects on the Prostate and Its Response to Castration in Senescent C
- Valproic Acid II: Effects on Oxidative Stress, Mitochondrial Membrane Potential, and Cytotoxicity in Glutathione-Depleted Rat Hepatocytes
- Biphasic Lindane-Induced Oxidation of Glutathione and Inhibition of Gap Junctions in Myometrial Cells
- Induction of Hepatic Peroxisome Proliferation by 8–2 Telomer Alcohol Feeding In Mice: Formation of Perfluorooctanoic Acid in the Liver
- A Systems-Based Computational Model for Dose-Response Comparisons of Two Mode of Action Hypotheses for Ethanol-Induced Neurodevelopmental To
- Gene Ontology Mapping as an Unbiased Method for Identifying Molecular Pathways and Processes Affected by Toxicant Exposure: Application to A
- Role of HIF Signaling on Tumorigenesis in Response to Chronic Low-Dose Arsenic Administration
- Rapid Uptake, Metabolism, and Elimination of Inhaled Sulfuryl Fluoride Fumigant by Rats
- Altered Retinoid Metabolism in Female Long-Evans and Han/Wistar Rats following Long-Term 2,3,7,8-Tetrachlorodibenzo-p-Dioxin(TCDD)-Treatmen
- Ryanodine Receptor-Mediated Rapid Increase in Intracellular Calcium Induced by 7,8-Benzo(a)Pyrene Quinone in Human and Murine Leukocytes
- Ultrafine Carbon Black Particles Cause Early Airway Inflammation and Have Adjuvant Activity in a Mouse Allergic Airway Disease Model
- Research Strategies for Safety Evaluation of Nanomaterials, Part I: Evaluating the Human Health Implications of Exposure to Nanoscale Materi
- Genistein Enhancement of Respiratory Allergen Trimellitic Anhydride-induced IgE Production by Adult B6C3F1 Mice Following In Utero and Postn
- Effects of Chronic Dietary and Repeated Acute Exposure to Chlorpyrifos on Learning and Sustained Attention in Rats
- Validation and Development of a Predictive Paradigm for Hemotoxicology Using a Multifunctional Bioluminescence Colony-Forming Proliferation
- In Vitro Detection of Differential and Cell-Specific Hepatobiliary Toxicity Induced by Geldanamycin and 17-Allylaminogeldanamycin Using Dog
- Accumulation, Tissue Distribution, and Maternal Transfer of Dietary 2,3,7,8,-Tetrachlorodibenzo-p-Dioxin: Impacts on Reproductive Success of
- Interactions of Chronic Lead Exposure and Intermittent Stress: Consequences for Brain Catecholamine Systems and Associated Behaviors and HPA
- Induction of Fibroblast Growth Factor-9 and Interleukin-1 Gene Expression by Motorcycle Exhaust Particulate Extracts and Benzo(a)pyrene in H
- Chronic Oral Treatment with 13-cis-Retinoic Acid(Isotretinoin) or all-trans-Retinoic Acid Does Not Alter Depression-Like Behaviors in Rats
- Species Differences in the Induction of Hepatocellular DNA Synthesis by Diethanolamine
- An Integrated Addition and Interaction Model for Assessing Toxicity of Chemical Mixtures
- Comparison of TCDD and PCB CYP1A Induction Sensitivities in Fresh Hepatocytes from Human Donors, Sprague-Dawley Rats, and Rhesus Monkeys and
- Trans, Trans-2,4-Decadienal, a Product Found in Cooking Oil Fumes, Induces Cell Proliferation and Cytokine Production Due to Reactive Oxygen
- Tumor Necrosis Factor--Independent Downregulation of Hepatic Cholesterol 7-Hydroxylase Gene in Mice Treated with Lead Nitrate
- Coplanar Polychlorinated Biphenyls Activate the Aryl Hydrocarbon Receptor in Developing Tissues of Two TCDD-Responsive lacZ Mouse Lines
- Acute and Long-Lasting Cardiac Changes Following a Single Whole-Body Exposure to Sarin Vapor in Rats
- Butylhydroquinone Protects Cells Genetically Deficient in Glutathione Biosynthesis from Arsenite-Induced Apoptosis Without Significantly Cha
- Progress towards Development of an Amphibian-Based Thyroid Screening Assay Using Xenopus laevis. Organismal and Thyroidal Responses to the M
- DNA Hypomethylation Induced by Drinking Water Disinfection By-Products in Mouse and Rat Kidney
- Evaluation of Estrogenic Activities of Aquatic Herbicides and Surfactants Using an Rainbow Trout Vitellogenin Assay
- A Unifying Concept for Assessing Toxicological Interactions: Changes i
- Research Strategies for Safety Evaluation of Nanomaterials, Part III:
- In Silico Methods for Evaluating Human Allergenicity to Novel Proteins
- Role of CYP2E1 in the Epoxidation of Acrylamide to Glycidamide and For
- Use of a Rainbow Trout Oligonucleotide Microarray to Determine Transcr
- Tsc2 Expression Increases the Susceptibility of Renal Tumor Cells to A
- Azoxymethane Is a Genetic Background-Dependent Colorectal Tumor Initia
- Involvement of the Integrin-Linked Kinase Pathway in Hexachlorobenzene
- Long-Term Effects of a Standardized Complex Mixture of Urban Dust Part
- Detection of Thyroid System–Disrupting Chemicals Using in Vitro and in
- Exposure to Polybrominated Diphenyl Ethers(PBDEs): Changes in Thyroid
- Induction of Cytochrome P450 1A5 mRNA, Protein and Enzymatic Activitie
- Formulation and Characterization of an Experimental PCB Mixture Design
- In Vitro Cytotoxicity of Nanoparticles in Mammalian Germline Stem Cell
- Arginase Activity Differs with Allergen in the Effector Phase of Ovalb
- A Study of the Relationship between Cornea Permeability and Eye Irrita
- Inhibition and Induction of Aromatase(CYP19) Activity by Brominated F
- Behavioral and Pathological Effects in the Rat Define Two Groups of Ne
- D-Optimal Experimental Designs to Test for Departure from Additivity i
- Neurobiological Effects of Bisphenol A May Be Mediated by Somatostatin
- Effect of Chronic Exposure to Aluminium on Isoform Expression and Acti
- Methoxychlor Inhibits Brain Mitochondrial Respiration and Increases Hy
- Low-Level Subchronic Exposure to Wood Smoke Exacerbates Inflammatory R
- Comparative Pulmonary Toxicity Inhalation and Instillation Studies wit
- Effect of N-Acetylcysteine on Lipopolysaccharide-Induced Intra-uterine
- In Utero and Lactational Exposure to TCDD; Steroidogenic Outcomes Diff
- Protective Effect of Quercetin on Aroclor 1254–Induced Oxidative Damag
- Roles of Exercise and Pharmacokinetics in Cerivastatin-Induced Skeleta
- Pharmacologic and Toxicologic Evaluation of C. novyi-NT Spores
- Modulating the Endoplasmic Reticulum Stress Response with trans-4,5-Di
- Chemical Effects in Biological Systems—Data Dictionary(CEBS-DD): A Co
- Basal and Zinc-Induced Metallothionein in Resistance to Cadmium, Cispl
- Effects of Subchronically Inhaled Carbon Black in Three Species. I. Re
- Role of Organic Anion and Amino Acid Carriers in Transport of Inorgani
- Toxicological Effects of Gestational and Lactational Exposure to a Mix
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