【摘要】目的 评价晚期食管癌患者肿瘤组织XB130表达对顺铂化疗效果的影响。方法 real-time PCR方法检测晚期食管癌患者活检组织中XB130基因的表达，通过食管造影技术评价患者接受顺铂化疗后瘤体的缩小程度。结果 XB130基因在晚期食管癌患者肿瘤组织中存在不同程度表达，平均表达强度为正常组织的6.89倍，XB130表达的高低与顺铂化疗效果存在明显负相关，相关系数为0.7462。结论 晚期食管癌患者肿瘤组织XB130的表达可能降低患者对顺铂化疗的敏感性。

    【关键词】XB130；顺铂；晚期食管癌

    【中图分类号】R735.1 【文献标识码】A 【文章编号】ISSN.2095.6681.2018.32..02

    【Abstract】Objective To evaluate the impact of XB130 expression on the sensitivity of chemotherapy to cisplatin in advanced esophageal carcinoma patients.Methods Quantitative real-time PCR was performed to determine the XB130 mRNA expression levels using the comparative threshold cycle method of relative quantitation. Esophagogram was used in evaluating the variation of tumor after the chemotherapy to cisplatin in advanced esophageal carcinoma patients.Results Advanced esophageal carcinoma patients showed low or moderate expression ......