胃癌患者VEGF及SSTR表达及与胃癌的相关性研究(1)
【摘要】 目的：探讨胃癌患者VEGF与SSTR表达以及两者之间的相关性。方法：选取2010年1月-2014年12月就诊于本院的胃癌患者90例作为胃癌组，另取同期于本院体检的60例健康者作为对照组，采用免疫组织化学染色检测VEGF及SSTR在不同胃黏膜组织中的表达情况。结果：胃癌组VEGF表达阳性56例，阳性率为62.2%；对照组正常胃黏膜组中VEGF表达阳性5例，阳性率为8.3%，胃癌组VEGF表达阳性率高于对照组，比较差异具有统计学意义(P<0.05)。胃癌组SSTR1表达阳性73例，阳性率为81.1%，SSTR2表达阳性67例，阳性率为74.4%，SSTR3表达阳性47例，阳性率为52.2%。对照组SSTR1表达阳性47例，阳性率为78.3%，SSTR2表达阳性56例，阳性率为93.3%，SSTR3表达阳性51例，阳性率为85.5%。两组SSTR1阳性表达率比较差异无统计学意义(P>0.05)，胃癌组SSTR2、SSTR3表达阳性率低于对照组，比较差异具有统计学意义(P<0.05)。VEGF与SSTR2～3在胃癌组织中的表达存在显著相关性(P<0.05)，而与SSTR1的表达并未见显著相关性(P>0.05)。结论：VEGF在胃癌组织中高表达，而SSTR在胃癌组织中低表达，两者间呈显著负相关，表明在胃癌的发生发展调控中信号传导在上调VEGF的同时造成SSTR的丢失。
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【关键词】 胃癌； VEGF； SSTR； 相关性
【Abstract】 Objective： To study the expression of VEGF and SSTR and their correlations in patients with gastric cancer. Method： 90 patients with gastric cancer treated from January 2010 to December 2014 in our hospital were selected as gastric cancer group and 60 healthy check-ups were selected as control group. Through immunohistochemistry staining methods， the expression of VEGF and SSTR in different gastric mucosa tissues were detected. Result： The positive rate of VEFG in gastric cancer group was 62.2% (56 cases)； the positive rate of VEGF in the control group was 8.3% (5 cases) (P<0.05)； the gastric cancer group contained 73 positive cases in SSTR1 (81.1%)， 67 positive cases in SSTR2 (74.4%) and 47 positive cases in SSTR3 (52.2%)； the control group contained 47 positive cases in SSTR1 (78.3%)， 56 positive cases in SSTR2 (93.3%) and 51 positive cases in SSTR3 (85.5%)； the positive expression of SSTR1 of the two groups was not significantly different (P>0.05)； the positive rate of SSTR2 and SSTR3 of the gastric cancer group was lower than that of the control group (P<0.05). VEGF expression was significantly correlated with SSTR2 and SSTR3 expression in gastric cancer tissues (P<0.05)； VEGF expression was not closely correlated with SSTR1 expression (P>0.05). Conclusion： VEGF is highly expressed while SSTR is lowly expressed in gastric cancer tissues. VEGF is negatively correlated with SSTR， which indicates that the up-regulation of VEGF during signal transduction of occurrence and development of gastric cancer will cause the loss of SSTR.
, 百拇医药
【Key words】 Gastric cancer； VEGF； SSTR； Correlation
First-author’s address： Almond Altar Hospital Affiliated the First People’s Hospital， Shunde District， Foshan 528325， China
doi：10.3969/j.issn.1674-4985.2015.28.011
胃癌的死亡率在全世界恶性肿瘤中居第二位，是临床最为常见的恶性肿瘤之一[1]。提高胃癌早期诊断率是降低死亡率的重要途径。多项研究表明胃癌的浸润转移是多种基因及其蛋白表达产物协同作用的结果[2]。本研究通过检测胃癌组织血管内皮生长因子(VEGF)及生长抑素受体(SSTR)的表达情况，同时以健康者作为对照，以评判其在胃癌浸润和转移过程中的作用，为临床早期防治提供参考。, 百拇医药(梁君铭 曾宽 骆雪梅)
, http://www.100md.com
【关键词】 胃癌； VEGF； SSTR； 相关性
【Abstract】 Objective： To study the expression of VEGF and SSTR and their correlations in patients with gastric cancer. Method： 90 patients with gastric cancer treated from January 2010 to December 2014 in our hospital were selected as gastric cancer group and 60 healthy check-ups were selected as control group. Through immunohistochemistry staining methods， the expression of VEGF and SSTR in different gastric mucosa tissues were detected. Result： The positive rate of VEFG in gastric cancer group was 62.2% (56 cases)； the positive rate of VEGF in the control group was 8.3% (5 cases) (P<0.05)； the gastric cancer group contained 73 positive cases in SSTR1 (81.1%)， 67 positive cases in SSTR2 (74.4%) and 47 positive cases in SSTR3 (52.2%)； the control group contained 47 positive cases in SSTR1 (78.3%)， 56 positive cases in SSTR2 (93.3%) and 51 positive cases in SSTR3 (85.5%)； the positive expression of SSTR1 of the two groups was not significantly different (P>0.05)； the positive rate of SSTR2 and SSTR3 of the gastric cancer group was lower than that of the control group (P<0.05). VEGF expression was significantly correlated with SSTR2 and SSTR3 expression in gastric cancer tissues (P<0.05)； VEGF expression was not closely correlated with SSTR1 expression (P>0.05). Conclusion： VEGF is highly expressed while SSTR is lowly expressed in gastric cancer tissues. VEGF is negatively correlated with SSTR， which indicates that the up-regulation of VEGF during signal transduction of occurrence and development of gastric cancer will cause the loss of SSTR.
, 百拇医药
【Key words】 Gastric cancer； VEGF； SSTR； Correlation
First-author’s address： Almond Altar Hospital Affiliated the First People’s Hospital， Shunde District， Foshan 528325， China
doi：10.3969/j.issn.1674-4985.2015.28.011
胃癌的死亡率在全世界恶性肿瘤中居第二位，是临床最为常见的恶性肿瘤之一[1]。提高胃癌早期诊断率是降低死亡率的重要途径。多项研究表明胃癌的浸润转移是多种基因及其蛋白表达产物协同作用的结果[2]。本研究通过检测胃癌组织血管内皮生长因子(VEGF)及生长抑素受体(SSTR)的表达情况，同时以健康者作为对照，以评判其在胃癌浸润和转移过程中的作用，为临床早期防治提供参考。, 百拇医药(梁君铭 曾宽 骆雪梅)