冠心病患者血清纤维蛋白原\高敏C反应蛋白与粥样斑块不稳定性的关系研究(1)
 |
| 第1页 |
参见附件(2059KB，3页)。
[摘要] 目的:通过检测健康对照组及冠心病患者群血清纤维蛋白原(FIB)及炎性因子高敏C反应蛋白(hs-CRP)水平,探讨冠心病患者凝血功能紊乱、炎性因子表达与动脉粥样硬化斑块不稳定性的关系。方法:2007年10月～2008年8月于本院心内科行冠脉造影或冠脉CT患者195例,入院前均未行调脂治疗。按冠脉造影或冠脉CT结果分为健康对照组45例,冠心病患者150例,其中急性冠脉综合征(ACS)109例。入院当时检测血清脂蛋白、FIB、单核细胞趋化蛋白-1(MCP-1)、高敏C反应蛋白(hs-CRP)水平。结果:冠心病患者FIB,血清炎性因子MCP-1、hs-CRP、LDL-C水平明显升高(P<0.05),差异有统计学意义,表明患者存在炎性反应、脂代谢和凝血功能紊乱。与稳定型冠心病患者相比,ACS患者hs-CRP、FIB水平升高,差异有统计学意义, hs-CRP水平与FIB正相关,表明二者可能主要与动脉粥样硬化斑块的不稳定性相关。结论:急性冠脉综合征患者血清hs-CRP、FIB较稳定型冠心病患者明显升高,表明hs-CRP、FIB水平与冠状动脉斑块的不稳定性相关,对冠心病患者进行上述指标的检测有利于判断病情,尽早治疗,以改善预后。
[关键词] 纤维蛋白原;单核细胞趋化蛋白-1;高敏C反应蛋白;冠心病
[中图分类号] R541.4 [文献标识码]A [文章编号]1674-4721(2010)06(a)-018-03
Clinical characteristics of the correlation between serum high-sensitivity C reactive protein,fibrinogen levels and atheromatous plaque unstability of coronary artery
HU Ye1, ZHI Yongchao2, ZHANG Zhijing1,LIU Yonghua1,WANG Xinjie1
(1. Department of Emergency, Central Hospital of Dalian City,Liaoning Province, Dalian116033,China;2. Department of Circulation,Central Hospital of Dalian City, Liaoning Province,Dalian116033,China)
[Abstract] Objective :To investigate serum high-sensitivity C reactive protein(hs-CRP,fibrinogen(FIB) levels in patients with acute coronary syndrome(ACS) and steady coronary heart disease(SCHD) and their correlations with atheromatous plaque unstability of coronary artery. Methods:195 pateins were divided into two groups according to coronary artery angiography(CAG) from October 2007 to August 2008, 150 cases with CHD and 45 cases with normal coronary angiograms (no-CHD group), 109 patients with ACS among them, 41 pateints with SCHD. Serum HDL-C,MCP-1 and fibrinogen levels were measured at once coming into the hospital. Results: Serum LDL-C,HDL-C were significantly higher and lower in the CHD groups than in no-CHD groups. In pateints with ACS, serum hs-CRP,FIB were significantly higher than pateints with SCHD. Conclusion:The results indicate that hs-CRP,FIB are positively correlate with the atheromatous plaque unstability of coronary artery in pateints with ACS ......
您现在查看是摘要介绍页，详见PDF附件(2059KB，3页)。