替硝唑联合维生素C对牙周炎大鼠血清IgG1和IgG2a的影响(1)
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[摘要] 目的 探讨替硝唑联合维生素C对牙周炎大鼠的治疗作用及对血清IgG1和IgG2a的影响。 方法 给予牙周炎大鼠替硝唑联合维生素C处理(研究组)，并与单纯给予维生素作对照，分析处理后不同时间点的牙龈指数(gingival index，GI)、牙周附着丧失(attachment loss，AL)及血清IgG1和IgG2a水平。 结果 ①除2周的GI和AL外，两组治疗后各观察点的指标均优于治疗前；②研究组4周、6周和8周的AL和IgG2a水平低于对照组；③研究组6周和8周的GI低于对照组，IgG1水平高于对照组。 结论 联合治疗对牙周炎症状的改善效果优于单纯处理，并能纠正紊乱的IgG1和IgG2a水平。
[关键词] 替硝唑；维生素C；牙周炎；血清IgG1；血清IgG2a
[中图分类号] R781.4 [文献标识码] A [文章编号] 1673—9701(2012)26—0004—02
Effect of tinidazole combined with vitamin C on serum IgG1 and IgG2a of periodontitis rats
CHEN Zhouhua
Department of Stomatology， Zhoushan Maternal and Child Health Hospital in Zhejiang Province， Zhoushan 316000， China
[Abstract] Objective To explore the improvement effects of tinidazole combined with vitamin C on rats with periodontitis and the effects on serum IgG1 and IgG2a. Methods The rats with periodontitis were treated by combination therapy of tinidazole and vitamin C (research group)， while the control group was treated only with vitamin C. The following items at different treat time point were analyzed such as gingival index， attachment loss， serum IgG1 and IgG2a levels. Results ①Except the GI and AL at 2nd week， the other items at different time points of two groups were better than the condition before treatment； ②AL and IgG2a level at 4th， 6th and 8th week after treatment of research group were lower than control group； ③GI level at 6th and 8th week of research group were lower than control group， while the IgG1 were higher than control group. Conclusion The combination therapy of tinidazole and vitamin C show a better improvement effect than the pure vitamin C treatment with a possible mechanism to correct disorders of the IgG1 and IgG2a levels ......
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