硫酸镁联合硝苯地平和酚妥拉明治疗妊高症临床疗效观察(1)
【摘要】 目的 观察硫酸镁联合硝苯地平和酚妥拉明治疗妊娠高血压综合征(妊高症， PIH)的临床疗效。方法 105例PIH患者， 随机分为观察组(联合用药)53例， 对照组(单一用药)52例。其中对照组单用25%硫酸镁静脉滴注；观察组采用联合用药治疗， 即在对照组静脉滴注25%硫酸镁的基础上， 给予酚妥拉明同时口服硝苯地平控释片治疗。两组患者均治疗7 d。观察治疗效果。结果 治疗7 d后， 观察组总有效率96.2%， 对照组总有效率75.0%， 观察组临床疗效明显优于对照组， 组间比较差异具有统计学意义(P<0.05)， 两组治疗后平均动脉压(MAP)、红细胞比容(HCT)、24 h尿蛋白定量(PRO-U)及脐动脉血流速度峰谷比(S/D)较治疗前均有明显改善， 组内比较差异有统计学意义(P<0.05)， 两组治疗后各观察指标组间比较， 差异具有统计学意义(P<0.05)。结论 硫酸镁联合硝苯地平和酚妥拉明治疗PIH， 降压平稳， 解痉作用强， 临床疗效显著， 可有效减少围生期并发症的发生。
【关键词】 妊娠高血压综合征；硫酸镁；硝苯地平；酚妥拉明；疗效
, 百拇医药
DOI：10.14163/j.cnki.11-5547/r.2015.25.002
【Abstract】 Objective To observe clinical effect by magnesium sulfate combined with nifedipine and phentolamine in the treatment of pregnancy-induced hypertension (PIH). Methods A total of 105 PIH patients were randomly divided into observation group (combined medication) with 53 cases and control group (single medication) with 52 cases. The control group received 25% magnesium sulfate by intravenous drip. The observation group received additional phentolamine and oral administration of nifedipine tablets. Treatment for both groups lasted for 7 d. Their curative effects were observed. Results After 7 d of treatment， the total effective rate was 96.2% in the observation group， and 75.0% in the control group. The observation group had much better clinical effect than the control group， and their difference had statistical significance (P<0.05). Both groups had improved mean arterial pressure (MAP)， hematocrit value (HCT)， 24 h urine protein quantitation (PRO-U)， and peak and valley ratio of umbilical artery flow velocity (S/D) after treatment， comparing with those before treatment. The differences of these indexes before and after treatment in the two groups had statistical significance (P<0.05). The differences of these indexes between the two groups had statistical significance (P<0.05). Conclusion Implement of magnesium sulfate combined with nifedipine and phentolamine in the treatment of PIH provides stable decompression effect， strong spasmolysis effect， and remarkable clinical effects. This method can effectively reduce occurrence of perinatal complications.
, 百拇医药
【Key words】 Pregnancy-induced hypertension； Magnesium sulfate； Nifedipine； Phentolamine； Curative effect
妊娠高血压综合征(pregnancy-induced hypertension， PIH)简称妊高症， 为妊娠期特有的疾病， 是指妊娠20周以后出现高血压、水肿、蛋白尿3大症候群， 其基本病理生理变化是全身小动脉痉挛， 导致全身各组织器官因缺血、缺氧而受到不同程度的损害， 严重时可出现抽搐、昏迷、凝血功能障碍、心肾功能衰竭等症状， 是孕产妇及围生儿死亡的主要原因之一[1]。目前临床主要以解除痉挛、降低血压水平、增加心排血量、改善血液循环为治疗原则。大量国内文献[2， 3]表明硫酸镁是治疗PIH较为理想的首选药物， 具有镇静、抗痉挛以及降低颅内压等作用， 已广泛应用于临床。2012年9月～2014年7月本院采用硫酸镁联合硝苯地平和酚妥拉明治疗PIH， 取得了较好的临床效果， 现报告如下。, 百拇医药(钟燕珍 林凤琼 谭小平)
【关键词】 妊娠高血压综合征；硫酸镁；硝苯地平；酚妥拉明；疗效
, 百拇医药
DOI：10.14163/j.cnki.11-5547/r.2015.25.002
【Abstract】 Objective To observe clinical effect by magnesium sulfate combined with nifedipine and phentolamine in the treatment of pregnancy-induced hypertension (PIH). Methods A total of 105 PIH patients were randomly divided into observation group (combined medication) with 53 cases and control group (single medication) with 52 cases. The control group received 25% magnesium sulfate by intravenous drip. The observation group received additional phentolamine and oral administration of nifedipine tablets. Treatment for both groups lasted for 7 d. Their curative effects were observed. Results After 7 d of treatment， the total effective rate was 96.2% in the observation group， and 75.0% in the control group. The observation group had much better clinical effect than the control group， and their difference had statistical significance (P<0.05). Both groups had improved mean arterial pressure (MAP)， hematocrit value (HCT)， 24 h urine protein quantitation (PRO-U)， and peak and valley ratio of umbilical artery flow velocity (S/D) after treatment， comparing with those before treatment. The differences of these indexes before and after treatment in the two groups had statistical significance (P<0.05). The differences of these indexes between the two groups had statistical significance (P<0.05). Conclusion Implement of magnesium sulfate combined with nifedipine and phentolamine in the treatment of PIH provides stable decompression effect， strong spasmolysis effect， and remarkable clinical effects. This method can effectively reduce occurrence of perinatal complications.
, 百拇医药
【Key words】 Pregnancy-induced hypertension； Magnesium sulfate； Nifedipine； Phentolamine； Curative effect
妊娠高血压综合征(pregnancy-induced hypertension， PIH)简称妊高症， 为妊娠期特有的疾病， 是指妊娠20周以后出现高血压、水肿、蛋白尿3大症候群， 其基本病理生理变化是全身小动脉痉挛， 导致全身各组织器官因缺血、缺氧而受到不同程度的损害， 严重时可出现抽搐、昏迷、凝血功能障碍、心肾功能衰竭等症状， 是孕产妇及围生儿死亡的主要原因之一[1]。目前临床主要以解除痉挛、降低血压水平、增加心排血量、改善血液循环为治疗原则。大量国内文献[2， 3]表明硫酸镁是治疗PIH较为理想的首选药物， 具有镇静、抗痉挛以及降低颅内压等作用， 已广泛应用于临床。2012年9月～2014年7月本院采用硫酸镁联合硝苯地平和酚妥拉明治疗PIH， 取得了较好的临床效果， 现报告如下。, 百拇医药(钟燕珍 林凤琼 谭小平)