氨曲南治疗铜绿假单胞菌肺炎42例(1)
氨曲南治疗铜绿假单胞菌肺炎42例,单盲法,随机对照试验,铜绿假单胞菌感染,药物疗法,头孢他啶
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【摘要】 目的 评价氨曲南治疗铜绿假单胞菌肺炎的有效性和安全性。方法 入选病例76例,可评价病例72例,随机分为试验组和对照组,试验组42例,给予氨曲南1～2 g、iv、q12 h,疗程14～21 d;对照组30例,给予头孢他啶1～2 g、iv、q12 h,疗程14～21 d。结果 试验组、对照组有效率分别为90.5 %(38/42)和83.3 %(25/30) ; 细菌清除率88.1%和66.7%,不良反应发生率分别为9.1%(4/44)和9.4%(3/32)。2组间均无显著性差异(P>0.05)。结论 氨曲南治疗铜绿假单胞菌肺炎有效、安全,优于头孢他啶,值得推广应用。
【关键词】 氨曲南;单盲法;随机对照试验;铜绿假单胞菌感染;药物疗法;头孢他啶
The Clinical Utility of Atreonam in 42 Patients with Pseudomonas Aeruginosa Pneumonia
ZHANG Yan-guo,ZHANG Mei.
Wangkai Infectious Disease Hospital, Shandong Zaozhuang, Zao zhuang 277500, China
【Abstract】 Objective The present study sought to evaluate the clinical utility of atreonam in patients with pseudomonas aeruginosa pneumonia.Methods A total of 72 patients were finally enrolled in this study, and were randomly assigned to receive either atreonam (observation group, atreonam 1~2 g、iv、q12 h, 14~21 d, 42 patients) or Ceftazidime (contol group, Ceftazidime 1~2 g、iv、q12 h, 14~21 d, 20 patients) Results The total cure and efficiency rate were 76 ......
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