【摘要】 目的 比较氟伏沙明与帕罗西汀治疗强迫症的疗效及安全性。方法 分别用氟伏沙明和帕罗西汀治疗强迫症患者各36例，采用Yale-Brown强迫量表、汉密尔顿抑郁量表(HAMD)及不良反应量表(TESS)评定疗效和不良反应。结果 氟伏沙明和帕罗西汀疗效相似，差异无统计学意义，氟伏沙明起效慢于帕罗西汀，其不良反应也少于帕罗西汀。结论 氟伏沙明治疗强迫症安全有效，值得推广。

    【关键词】 氟伏沙明；帕罗西汀；强迫症；不良反应

    A control study of fluvoxamine and paroxetine in the treatment of obsessive-compulsive disorder

    TAN Wei，WANG Yi,GONG Fei-zhong,et al. Zigong Mental Health Center,Zigong 643000，China

    【Abstract】 Objective To compare the efficacy and side effects of fluvoxamineine and paroxetine in the treatment of obsessive-compulsive disorder(OCD).Methods 72 patients with OCD were randomly assigned into fluvoxamineine group and paroxetinegroup.The efficacy was measured with Yale-Brown and Hamilton Depression Scale(HAMD).The side effects were deter-mined by the Treatment Emergent Symptom Scale(TESS).Results There was no significant difference in the efficacy between two groups.The side effects of fluvoxamineine were lower than those of paroxetine.Conclusion Fluvoxamineine in the treatment of OCD is effective and safe. ......