苏子降气汤治疗痰浊壅肺型慢性阻塞性肺疾病稳定期的疗效观察(1)
摘要目的：觀察苏子降气汤对痰浊壅肺型慢性阻塞性肺疾病的临床疗效，同时评估其对肺功能改善的影响。方法：选取2016年1月至2017年12月北京中医药大学附属东方医院收治的痰浊壅肺型慢性阻塞性肺疾病患者60例，按照随机数字表法随机分为对照组和观察组，每组30例，对照组接受单纯西药治疗，观察组为中西医结合治疗，观察组予以西药+苏子降气汤治疗，均连续治疗30 d，比较2组临床疗效、治疗前后症候积分6 min步行测试、血气分析(氧分压浓度PaO2)、肺功能以及呼出气一氧化氮水平(FeNO)的差异。结果：对照组及观察组临床总有效率分别为8667%、6667%，统计分析后显示观察组优于对照组。2组的临床症候积分、6 min步行距离、氧分压浓度、肺功能水平均较治疗前改善，观察组改善更显著，差异有统计学意义(P<005)。治疗后2组FeNO均有下降，其中观察组下降更明显，差异有统计学意义(P<005)。结论：苏子降气汤对痰浊壅肺型慢性阻塞性肺疾病有显著临床疗效，可改善患者的肺通气，其作用机制可能与减少FeNO浓度有关。
关键词慢性阻塞性肺疾病；痰浊壅肺型；稳定期；苏子降气汤；肺功能；FeNO
Curative Effect Observation of Suzi Jiangqi Decoction in the Treatment of Chronic Obstructive Pulmonary Disease with Phlegmturbidity Accumulation Syndrome at Stable Stage
Li Niuniu，Shi Liqing，Ma Jianling，Ji Kun，Wen Shaohui，Wang Liyun
(Department of Respiration Fever Disease，Dongfang Hospital，Beijing University of Chinese Medicine，Beijing 100071，China)
AbstractObjective：To observe the clinical curative effect of Suzi Jiangqi Decoction in the treatment of chronic obstructive pulmonary disease with phlegmturbidity accumulation syndrome，and to evaluate the effects on pulmonary function improvement.Methods：A total of 60 cases of phlegmturbidity accumulation in patients with chronic obstructive pulmonary disease in our hospital from January 2016 to December 2017 as the research object，were randomly divided into the western medicine group (WM group) (30 cases) and the combination of traditional Chinese and western medicine group (TCM and WM group) (30 cases) by the digital random method.The western medicine group took the simple western medicine treatment，and the combination of TCM and WM group had western medicine treatment + Suzi Jiangqi Decoction，continuous treatment for 30 d.The differences between the two groups with clinical curative effect，symptom integrals and arterial blood gas analysis (oxygen partial pressure concentration PaO2)，pulmonary function and fractional exhaled nitric oxide (FeNO) before and after the treatment were compared.Results：The clinical total effective rate of the WM group and the combination of TCM and WM group were respectively 8667% and 6667%.The statistical analysis showed that the combination of TCM and WM group was superior to the WM group.The clinical symptoms integrals，6 min walking distance，concentration of oxygen partial pressure，pulmonary function levels of both groups were improved.The combination of TCM and WM group improved more significantly，and the differences were statistically significant (P<005).FeNO decreased in both groups after the treatment.The combination of TCM and WM group decreased more significantly，and the differences were statistically significant (P<005).Conclusion：Suzi Jiangqi Decoction was with significant clinical curative effect in phlegmturbidity accumulation syndrome of chronic obstructive pulmonary disease，can improve pulmonary ventilation in the patients.The mechanism may be related to the reduction of FeNO concentration., 百拇医药(李扭扭 史利卿 马建岭)
关键词慢性阻塞性肺疾病；痰浊壅肺型；稳定期；苏子降气汤；肺功能；FeNO
Curative Effect Observation of Suzi Jiangqi Decoction in the Treatment of Chronic Obstructive Pulmonary Disease with Phlegmturbidity Accumulation Syndrome at Stable Stage
Li Niuniu，Shi Liqing，Ma Jianling，Ji Kun，Wen Shaohui，Wang Liyun
(Department of Respiration Fever Disease，Dongfang Hospital，Beijing University of Chinese Medicine，Beijing 100071，China)
AbstractObjective：To observe the clinical curative effect of Suzi Jiangqi Decoction in the treatment of chronic obstructive pulmonary disease with phlegmturbidity accumulation syndrome，and to evaluate the effects on pulmonary function improvement.Methods：A total of 60 cases of phlegmturbidity accumulation in patients with chronic obstructive pulmonary disease in our hospital from January 2016 to December 2017 as the research object，were randomly divided into the western medicine group (WM group) (30 cases) and the combination of traditional Chinese and western medicine group (TCM and WM group) (30 cases) by the digital random method.The western medicine group took the simple western medicine treatment，and the combination of TCM and WM group had western medicine treatment + Suzi Jiangqi Decoction，continuous treatment for 30 d.The differences between the two groups with clinical curative effect，symptom integrals and arterial blood gas analysis (oxygen partial pressure concentration PaO2)，pulmonary function and fractional exhaled nitric oxide (FeNO) before and after the treatment were compared.Results：The clinical total effective rate of the WM group and the combination of TCM and WM group were respectively 8667% and 6667%.The statistical analysis showed that the combination of TCM and WM group was superior to the WM group.The clinical symptoms integrals，6 min walking distance，concentration of oxygen partial pressure，pulmonary function levels of both groups were improved.The combination of TCM and WM group improved more significantly，and the differences were statistically significant (P<005).FeNO decreased in both groups after the treatment.The combination of TCM and WM group decreased more significantly，and the differences were statistically significant (P<005).Conclusion：Suzi Jiangqi Decoction was with significant clinical curative effect in phlegmturbidity accumulation syndrome of chronic obstructive pulmonary disease，can improve pulmonary ventilation in the patients.The mechanism may be related to the reduction of FeNO concentration., 百拇医药(李扭扭 史利卿 马建岭)
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