血浆同型半胱氨酸水平与脑梗死的相关性研究(1)
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[摘要] 目的：观察血浆同型半胱氨酸水平与脑梗死的相关性。方法：选择2009年10月~2010年10月我院收治的脑梗死患者84例作为观察组，又根据发作情况分为首发组(40例)和复发组(44例)。体检正常者52例作为对照组，检测并对比组间空腹血浆同型半胱氨酸水平。结果：观察组同型半胱氨酸血浆含量为(29.35±3.39) μmol/L，对照组为(12.15±1.66) μmol/L，两组比较差异有统计学意义(t=5.705，P<0.05)；首发组与复发组比较，差异有统计学意义(t=-3.751，P<0.05)。在血浆同型半胱氨酸四个水平患者的百分率，复发组与首发组间差异均有统计学意义，中重度增高者(81.9%)明显高于首发组(45.0%)。结论：高同型半胱氨酸血症与脑梗死有关，且水平越高，复发几率越大。
[关键词] 同型半胱氨酸；脑梗死；相关性
[中图分类号] R446.1 [文献标识码]B [文章编号]1673-7210(2011)04(b)-078-02
The relevance between plasma homocysteine levels and cerebral infarction
ZHANG Shiyong, GAO Tian, SUN Jian, LIU Qi, TIAN Rong, MAO Gengsheng
Department of Vascular Surgery, Armed Police General Hospital, Beijing 100039, China
[Abstract] Objective: To observe the relevance of blood plasma homocystein level and cerebral infarction. Methods: 84 patients with cerebral infarction were selected as the observation group, who were treated in our hospital from October 2009 to October 2010. Patients were divided into initial attack group and recurrent group. We chose 52 patients with normal physical examination as a control group. Plasma homocysteine levels were detected and compared between groups. Results: The patients' plasma concentration of homocysteine was (29.35±3.39) μmol/L in observation group, while it was (12.15±1.66) μmol/L in control group. The difference was statistically significant (t=5.705, P<0.05) between the two groups. And between initial and recurrent group, the difference of concentration of also was statistically significant (t=-3.751, P<0.05). In addition, the percentage of patients in initial group and recurrent group were significant differences among the four plasma homocysteine level. Compared with those in initial group, patients in the recurrent group were significantly more in moderate and severe plasma homocysteine levels (81.9%∶45.0%).Conclusion: High homocysteine relate to cerebral infarction, and the higher the level, the greater the risk of recurrence.
[Key words] Homocystein; Cerebral infarction; Relevance
同型半胱氨酸为体内蛋氨酸和半胱氨酸代谢的中间产物，近年来随着对其研究的不断深入 ......
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