伊班膦酸钠治疗多发性骨髓瘤骨痛及高钙血症疗效观察(1)
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[摘要] 目的：观察及分析应用伊班膦酸钠治疗多发性骨髓瘤患者骨痛及高钙血症的疗效。方法：选择2005年1月～2010年4月我科应用伊班膦酸钠治疗的多发性骨髓瘤患者30例，对患者资料进行回顾性分析。30例多发性骨髓瘤患者每21天应用伊班膦酸钠4 mg静点，观察使用伊班膦酸钠前后骨痛缓解率及血钙浓度变化，判定伊班膦酸钠治疗多发性骨髓瘤的疗效。结果：30例患者应用伊班膦酸钠前血钙浓度为(3.22±1.2) mmol/L，用药后血钙浓度为(2.42±0.57) mmol/L，用药后血钙浓度明显减低，差异有统计学意义。用药后骨痛缓解总有效率达80.00%。结论：伊班膦酸钠能有效缓解多发性骨髓瘤患者骨痛，降低血钙，治疗高钙血症。
[关键词] 伊班膦酸钠；多发性骨髓瘤；高钙血症
[中图分类号] R733.3[文献标识码]B [文章编号]1673-7210(2010)11(a)-056-02
Efficacy of Ibandronate in the treatment of osteodynia and hypercalcemia in multiple myeloma
CHAI Hongyu
(Departemnt of Hematology, Panjin First People's Hospital, Liaoning province, Panjin 124010, China)
[Abstract] Objective: To observe and analyze the therapeutic effect of treatment with Ibandronate on bone pain and hypercalcemia in patients with multiple myeloma(MM). Methods：From year 2005 to 2010, 30 cases of multiple myeloma treated by Ibandronate were selected, the clinic data of those cases were analyzed retrospectively. 30 cases of multiple myeloma received intraveous injection of Ibandronate (4 mg) once three weeks. We observed the pain remission rate and serum calcium concentration between before and after treatment by Ibandronate, and to judgement of the effect of MM treated with Ibandronate. Results：The serum calcium concentration of all the 30 cases pretreatment was (3.22±1.2) mmol/L, and post-treatment was (2.42±0.57) mmol/L. The serum calcium levels were decreased in patients with MM after treatment by Ibandronate. The difference was statistically significant (P<0.05). The total effective rate of pain remission was 80.00%. Conclusion: Ibandronate can effectively relieve bone pain caused by Multiple Myeloma and drop serum calcium, to treat hypercalcemia.
[Key words] Ibandronate; Multiple Myeloma; Hypercalcemia
多发性骨髓瘤 (multiple myeloma)是一种单克隆的浆细胞异常增生的恶性肿瘤，占恶性肿瘤的1%～2%，占血液系统恶性肿瘤的10%。欧美国家年发生率是2/10万～5/10万，我国发病率约为1/10万，主要集中在老年人，发病年龄50～70岁，中位年龄55岁，40岁以下者少见，男:女约为3:1，近二十年来发病率有上升趋势。骨质损害是多发性骨髓瘤的重要临床表现之一，包括全身骨质疏松、溶骨性病变、病理性骨折和高钙血症。患者最初常表现为骨痛，随着疾病进展程度逐渐加重并可出现病理性骨折，最常累及的椎骨压缩性骨折更可导致脊柱变形、脊髓受压进而引起长期的疼痛，严重影响了患者的生活质量。因此，预防和治疗多发性骨髓瘤骨骼并发症以提高患者的生活质量就更加重要。部分多发性骨髓瘤患者伴有高钙血症， 2005年1月～2010年4月五年内我科采用伊班膦酸钠针对多发性骨髓瘤患者的骨痛及高钙血症进行治疗共30例，取得良好效果，现报道如下：
1资料与方法
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