四种血清肿瘤标志物联合检测对肺癌的诊断价值(1)
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[摘要] 目的：探讨癌胚抗原(CEA)、糖链抗原125(CA125)、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)四项指标联合检测在肺癌诊断中的价值。方法：应用电化学发光技术和放射免疫法检测60例正常对照，60例肺癌和60例肺良性疾病血清中的CEA、CA125、NSE、CYFRA21-1的含量。结果：肺癌组四项指标均明显高于肺良性疾病组和健康对照组，差异具有统计学意义(P<0.01)。四项指标联合检测可显著提高肺癌诊断的敏感性和特异性。结论：四项指标对肺癌诊断具有一定的价值，且联合检测具有较高的临床实用价值。
[关键词] 肺瘤标志物；肺癌；癌胚抗原；糖链抗原125；神经元特异性烯醇化酶；细胞角蛋白19片段
[中图分类号] R734.2[文献标识码]A [文章编号]1673-7210(2010)11(a)-027-02
Diagnostic significance of four serum tumor makers measured together for lung cancer
CHEN Tingjian, LIN Qunying, XU Meimei
(Department of Respiratory Medicine, the Affiliated Hospital of Putian University, Putian 351100, China)
[Abstract] Objective: To study the diagnostic significance of four serum tumor markers(CEA, CA125, NSE, and CYFRA21-1) measured together for lung cancer. Methods: The four serum level of CEA, CA125, NSE and CYFRA21-1 was tested by the electro-chemiluminescence technic and the radioimmunoassay (RIA) among 60 patients with lung cancer and compared to 60 patients with benign lung diseases and 60 healthy people. Results: The level of the four serum tumor markers in the 60 patients with lung cancer was markedly higher than that in the 60 patients with benign lung diseases and 60 healthy people, and the differences had statistical significance (P<0.01). The four serum level measured together could evidently enhance sensitivity and specificity of lung cancer diagnose. Conclusion: The four serum level of CEA, CA125, NSE and CYFRA21-1 is significant to the diagnosis of lung cancer and the four level measured together has the clinical practical value.
[Key words] Tumor marker; Lung cancer; CEA; CA125; NSE; CYFRA21-1
肺癌是当今世界上严重危害人类健康与生命的常见恶性肿瘤，全世界每年死于肿瘤的大约有1/3死于肺癌[1]，早期诊断是提高癌症患者治愈率和生存率的关键。肺癌的常用诊断方法有胸片、胸部CT、纤维支气管镜及经皮肤肺穿刺活检等，现血清中肿瘤标志物在恶性肿瘤的诊断及预后判断中得到了广泛的应用，且近年来理论和实践都提倡同时检测多个肿瘤标志物以提高诊断的准确性，并对肿瘤来源判断有一定的辅助意义[2]。本文采用四项指标联合检测，分析其价值，现报道如下：
1 资料与方法
1.1 一般资料
肺癌组：60例均为我科2006年1月～2009年3月的住院患者，经组织病理学或细胞学证实为原发性肺癌 ......
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