茶碱缓释片的制备工艺对释放度的影响研究(1)
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[摘要] 目的:以乙基纤维素为骨架材料,以羟丙基甲基纤维素为致孔剂制成茶碱缓释骨架片,考察羟丙基甲基纤维素(HPMC)、乙基纤维素(EC)与茶碱缓释片释放度的关系以及制备工艺对茶碱缓释片体外释药速度的影响。方法:均匀设计实验,对茶碱缓释片进行体外释放度测定。结果:用羟丙基甲基纤维素制备的茶碱缓释片,释放度数据较稳定;调整羟丙基甲基纤维素和乙基纤维素用量配比,湿法制粒所得骨架片的释药速度比干法直接压片有所减慢;压片力的大小对释药速度也有一定的影响。结论:通过对茶碱缓释片制备工艺条件的考察,找到了适合生产的制备工艺,使药效稳定,提高了茶碱用药的安全性和有效性。
[关键词] 茶碱缓释片;羟丙基甲基纤维素(HPMC);乙基纤维素(EC);释放度
[中图分类号] R944.4 [文献标识码]A [文章编号]1673-7210(2010)03(a)-042-03
Influence of the preparation craft of Theophylline Sustained Release Tablets on the drug release
HUANG Haowu1, LUO Yuhong1, LIANG Feihua2
(1.The People's Hospital of Zhuhai, Zhuhai 519000, China; 2.The Second People's Hospital of Zhuhai, Zhuhai 519000, China)
[Abstract] Objective: To prepare the Theophylline Sustained Release Matrix Tablets with ethyl cellulose as the matrix material and hydroxy propyl methylcellulose as the pore-forming agent, investigate the relationships between hydroxy propyl methylcellulose (HPMC), ethyl cellulose (EC) and the drug release of Theophylline Sustained Release Tablets, and investigate the influence of the preparation craft of Theophylline Sustained Release Tablets on the release rate ......
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