复方氨苯蝶啶的急性毒性及其保钾作用(1)
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[摘要] 目的：考察复方氨苯蝶啶的安全性及其保钾作用。方法：将NIH小鼠及SD大鼠分别用6%氨苯蝶啶、30%氢氯噻嗪和复方氨苯蝶啶混悬液灌胃，观察氨苯蝶啶、氢氯噻嗪及复方氨苯蝶啶的急性毒性及对尿钾的影响。结果：与氨苯蝶啶、氢氯噻嗪的急性毒性相比，复方氨苯蝶啶的急性毒性较低。氢氯噻嗪组排尿量和排钾量与对照组比较显著升高(P<0.01)，氨苯蝶啶组排尿量增加不明显，但明显减少排钾(P<0.01)；复方氨苯蝶啶组明显增加排尿量(P<0.01)，排钾量略减少。结论：复方氨苯蝶啶的安全性好，氨苯蝶啶与氢氯噻嗪合用可增加利尿效应并预防低钾血症。
[关键词] 复方氨苯蝶啶；急性毒性；保钾作用
[中图分类号] R983+.1[文献标识码]A [文章编号]1673-7210(2008)06(c)-011-02
Acute toxicity and potassium-sparing effect of Compound Triamterene
WU Xiao-lin1，ZHONG Gui-ling1 ,LIN Mei-ling1 ,CUI Guo-hua2
(1.The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630，China; 2. Guangzhou Baiyunshan Pharmaceutcal Co.LTD, Guangzhou 510515，China)
[Abstract] Objective:To investigate the safety and the potassium-sparing effect of Compound Triamterene. Methods:NIH mice and SD rats were given 6% Triamterene, 30% Hydrochlorothiazide and Compound Triamterene by mouth.Acute toxicity and potassium-sparing effects of Triamterene, Hydrochlorothiazide and Compound Triamterene were observed.Results:The acute toxicity of Compound Triamterene was lower than that ofTriamterene or Hydrochlorothiazide.The urinary excretion and potassium excretion in Hydrochlorothiazide group were markedly higher than that of control group(P
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