富血小板血浆PRP结合自体脂肪颗粒移植早期对面部年轻化的影响(1)
[摘要]目的：探讨富血小板血浆(platelet rich plasma，PRP)结合自体脂肪颗粒移植早期在面部年轻化的临床效果。方法：选取2017年5月-2018年7月于笔者医院整形烧伤外科行面部自体脂肪颗粒移植就医者58例，随机分为对照组和观察组，对照组单纯应用自体脂肪颗粒移植治疗方案，观察组使用PRP结合自体脂肪颗粒移植，治疗后3个月比较两组就医者面部皮下脂肪厚度及色斑改善情况，由就医者根据观察指标进行治疗效果评价。结果：两组治疗后3个月面部凹陷处厚度、色斑情况均较治疗前改善，且观察组改善情况优于对照组，差异有统计学意义(P<0.05)。术后无1例出现脂肪液化、感染、结节、坏死、血肿等术后并发症，且观察组满意度高于对照组，差异有统计学意义(P<0.05)。结论：PRP结合自体脂肪颗粒移植在面部年轻化中疗效更好，效果持久，就医者接受度高、满意度好，适宜在临床推广。
[关键词]富血小板血浆;自体脂肪颗粒移植;面部凹陷;脂肪厚度;面部年轻化;色斑;额部;颞部
[中图分类号]R622 [文献标志码]A [文章编号]1008-6455(2019)03-0015-05
Abstract： Objective To explore the clinical effect in the early stage of platelet rich plasma(PRP)combined with autologous fat granule transplantation on facial rejuvenation in early stage. Methods 58 patients who wanted to undergo autologous fat granule transplantation from May 2017 to July 2018 were randomly divided into the control group and the observation group. The control group was treated with autologous fat granule transplantation alone， while the observation group was treated with PRP combined with autologous fat granule transplantation. Three months after treatment， the facial subcutaneous fat thickness and the improvement of color spots were compared between the two groups， and the therapeutic effect was evaluated by the patients themselves according to the observation indicators. Results After 3 months of treatment， the thickness and stain of facial depression in the two groups were improved compared with those before treatment， and the improvement in the observation group was due to that in the control group， the differences were statistically significant (P<0.05). No complications such as fat liquefaction， infection， nodules， necrosis and hematoma occurred in the operation area of all patients. The satisfaction of patients in the observation group was higher than that in the control group (P<0.05). Conclusion PRP combined with autologous fat granule transplantation in the face of young chemotherapeutic effect is better， lasting effect， patient acceptance， satisfaction is high， suitable for clinical promotion.
Key words： platelet rich plasma (PRP); autologous fat granule transplantation; facial depression; fat thickness; facial rejuvenation; spots; forehead; temporal region
隨着社会的发展以及人们意识形态的改变，人们对于颜面轮廓协调、美丽的追求与日俱增。但随着年龄的增长，由于面部容量缺失、皮肤弹性逐渐降低、皮下脂肪含量减少以及深层软组织松弛等原因可导致额颞部、鼻唇沟、面颊部等局部凹陷，以及面部皮肤下垂、皱纹加深，致使面部轮廓发生改变、老化，严重影响爱美女性的精神状态以及日常生活。目前临床上用于改善面部老化状态的方式很多，包括面部浅表肌肉腱膜系统提紧手术、内窥镜除皱手术，以及创伤较小的肉毒毒素注射、激光治疗、软组织填充、硅胶假体填充、透明质酸填充、自体脂肪颗粒移植等[1-3]。传统的面部除皱手术对皮肤下垂效果较好，但对于面部凹陷的改善效果不佳，因此临床已不常应用[4]。目前透明质酸填充和自体脂肪颗粒移植在临床上应用较为广泛，自体脂肪颗粒移植因其取材方便、排异性小、安全性高等优点，在临床上更加受就医者青睐。但由于自体脂肪颗粒移植术后存在吸收率不稳定、脂肪组织存活率低、远期疗效不确定等问题，阻碍了自体脂肪颗粒移植技术在临床的广泛开展，因此如何提高自体脂肪颗粒移植的存活率成为临床研究的热点问题[5-6]。富血小板血浆(platelet rich plasma，PRP)同为人体自身组织，提取血液经过梯度离心、分离而得到的具有高浓度血小板、富含多种生物因子的血浆[7]，PRP通过释放多种组织生长因子改善组织成活率、促进血管再生，但对于PRP能否提高自体脂肪颗粒移植存活率，目前尚无定论[8-9]。近年来笔者医院整形烧伤科通过采用PRP联合自体脂肪颗粒移植改善面部老化取得非常好的临床效果，现报道如下。, http://www.100md.com(刘欢 刘俊辉 程飚)
[关键词]富血小板血浆;自体脂肪颗粒移植;面部凹陷;脂肪厚度;面部年轻化;色斑;额部;颞部
[中图分类号]R622 [文献标志码]A [文章编号]1008-6455(2019)03-0015-05
Abstract： Objective To explore the clinical effect in the early stage of platelet rich plasma(PRP)combined with autologous fat granule transplantation on facial rejuvenation in early stage. Methods 58 patients who wanted to undergo autologous fat granule transplantation from May 2017 to July 2018 were randomly divided into the control group and the observation group. The control group was treated with autologous fat granule transplantation alone， while the observation group was treated with PRP combined with autologous fat granule transplantation. Three months after treatment， the facial subcutaneous fat thickness and the improvement of color spots were compared between the two groups， and the therapeutic effect was evaluated by the patients themselves according to the observation indicators. Results After 3 months of treatment， the thickness and stain of facial depression in the two groups were improved compared with those before treatment， and the improvement in the observation group was due to that in the control group， the differences were statistically significant (P<0.05). No complications such as fat liquefaction， infection， nodules， necrosis and hematoma occurred in the operation area of all patients. The satisfaction of patients in the observation group was higher than that in the control group (P<0.05). Conclusion PRP combined with autologous fat granule transplantation in the face of young chemotherapeutic effect is better， lasting effect， patient acceptance， satisfaction is high， suitable for clinical promotion.
Key words： platelet rich plasma (PRP); autologous fat granule transplantation; facial depression; fat thickness; facial rejuvenation; spots; forehead; temporal region
隨着社会的发展以及人们意识形态的改变，人们对于颜面轮廓协调、美丽的追求与日俱增。但随着年龄的增长，由于面部容量缺失、皮肤弹性逐渐降低、皮下脂肪含量减少以及深层软组织松弛等原因可导致额颞部、鼻唇沟、面颊部等局部凹陷，以及面部皮肤下垂、皱纹加深，致使面部轮廓发生改变、老化，严重影响爱美女性的精神状态以及日常生活。目前临床上用于改善面部老化状态的方式很多，包括面部浅表肌肉腱膜系统提紧手术、内窥镜除皱手术，以及创伤较小的肉毒毒素注射、激光治疗、软组织填充、硅胶假体填充、透明质酸填充、自体脂肪颗粒移植等[1-3]。传统的面部除皱手术对皮肤下垂效果较好，但对于面部凹陷的改善效果不佳，因此临床已不常应用[4]。目前透明质酸填充和自体脂肪颗粒移植在临床上应用较为广泛，自体脂肪颗粒移植因其取材方便、排异性小、安全性高等优点，在临床上更加受就医者青睐。但由于自体脂肪颗粒移植术后存在吸收率不稳定、脂肪组织存活率低、远期疗效不确定等问题，阻碍了自体脂肪颗粒移植技术在临床的广泛开展，因此如何提高自体脂肪颗粒移植的存活率成为临床研究的热点问题[5-6]。富血小板血浆(platelet rich plasma，PRP)同为人体自身组织，提取血液经过梯度离心、分离而得到的具有高浓度血小板、富含多种生物因子的血浆[7]，PRP通过释放多种组织生长因子改善组织成活率、促进血管再生，但对于PRP能否提高自体脂肪颗粒移植存活率，目前尚无定论[8-9]。近年来笔者医院整形烧伤科通过采用PRP联合自体脂肪颗粒移植改善面部老化取得非常好的临床效果，现报道如下。, http://www.100md.com(刘欢 刘俊辉 程飚)