舒芬太尼复合地佐辛用于痔上黏膜环切术后自控镇痛的剂量分析(1)
摘要：目的 探讨不同剂量舒芬太尼复合地佐辛用于痔上黏膜环切术后自控镇痛对镇静效果及疼痛程度的影响。方法 选择2015年7月～2018年6月在我院行痔上黏膜环切术治疗的96例患者，随机分为观察组和对照组，各48例。观察组给予1.5 μg/kg舒芬太尼复合0.3 mg/kg地佐辛，对照组给予2 μg/kg舒芬太尼。比较两组镇静评分及术后疼痛程度。结果 观察组术后6、12、24及48 h镇静评分分别为(2.10±0.15)分、(2.42±0.19)分、(3.05±0.20)分及(3.96±0.45)分，均高于对照组的(1.38±0.18)分、(2.05±0.16)分、(2.56±0.22)分及(3.18±0.23)分，术后6、12、24及48 h疼痛评分分别为(6.59±0.96)分、(4.24±1.53)分、(2.02±1.26)分及(0.95±0.36)分，均低于对照组的(8.23±1.14)分、(6.18±1.22)分、(4.63±1.37)分及(2.48±1.19)分，差异具有统计学意义(P<0.05)。结论 痔上黏膜环切术患者术后自控镇痛中采取舒芬太尼复合地佐辛镇痛效果理想，利于降低患者疼痛程度，促进患者康复。
, 百拇医药
关键词：痔上黏膜环切术;自控镇痛;舒芬太尼;地佐辛;剂量
中图分类号：R614 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.045
文章编号：1006-1959(2019)04-0140-02
Abstract：Objective To investigate the effects of different doses of sufentanil combined with dizocine on the sedative effect and pain degree of self-controlled analgesia after supraorbital mucosal circumcision. Methods 96 patients who underwent sacral circumcision in our hospital from July 2015 to June 2018 were randomly divided into observation group and control group， 48 cases each. The observation group was given 1.5 μg/kg sufentanil combined with 0.3 mg/kg dysone， and the control group was given 2 μg/kg sufentanil. The sedation scores and postoperative pain levels were compared between the two groups. Results The sedation scores of the observation group at (2.10±0.15)， (2.42±0.19)， (3.05±0.20) and (3.96±0.45) were higher than those of the control group at 6， 12， 24 and 48 h after operation(1.38±0.18)， (2.05±0.16)， (2.56±0.22) and (3.18±0.23)， the pain scores at 6， 12， 24 and 48 h were (6.59±0.96)，(4.24±1.53)， (2.02±1.26) and (0.95±0.36)， respectively， All were lower than the control group (8.23±1.14)， (6.18±1.22)， (4.63±1.37) and (2.48±1.19)， the difference was statistically significant (P<0.05). Conclusion Sufentanil combined with dextrozine is effective in the postoperative analgesia of patients with supraorbital mucosa. It is beneficial to reduce the pain level and promote the recovery of patients.
Key words：Supraorbital mucosal circumcision;Self-controlled analgesia;Sufentanil;Dizocine;Dose
痔是臨床上常见的肛门疾病，主要临床表现为肛门疼痛、瘙痒及间歇性便后出血等，给患者心理及生理均造成严重影响[1]。目前临床常采取手术治疗，痔上黏膜环切术利用吻合器环形切除，促使肛垫上移并固定，可有效达到治疗目，但术后患者易产生剧烈疼痛[2]。因此，给予科学合理的麻醉剂量，对缓解缓解术后疼痛，改善镇静效果具有重要作用。鉴于此，本研究进一步探讨痔上黏膜环切术后自控镇痛采取不同剂量舒芬太尼复合地佐辛对疼痛程度及镇静效果的影响，报道如下。, 百拇医药(张燕 王永娟)
, 百拇医药
关键词：痔上黏膜环切术;自控镇痛;舒芬太尼;地佐辛;剂量
中图分类号：R614 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.045
文章编号：1006-1959(2019)04-0140-02
Abstract：Objective To investigate the effects of different doses of sufentanil combined with dizocine on the sedative effect and pain degree of self-controlled analgesia after supraorbital mucosal circumcision. Methods 96 patients who underwent sacral circumcision in our hospital from July 2015 to June 2018 were randomly divided into observation group and control group， 48 cases each. The observation group was given 1.5 μg/kg sufentanil combined with 0.3 mg/kg dysone， and the control group was given 2 μg/kg sufentanil. The sedation scores and postoperative pain levels were compared between the two groups. Results The sedation scores of the observation group at (2.10±0.15)， (2.42±0.19)， (3.05±0.20) and (3.96±0.45) were higher than those of the control group at 6， 12， 24 and 48 h after operation(1.38±0.18)， (2.05±0.16)， (2.56±0.22) and (3.18±0.23)， the pain scores at 6， 12， 24 and 48 h were (6.59±0.96)，(4.24±1.53)， (2.02±1.26) and (0.95±0.36)， respectively， All were lower than the control group (8.23±1.14)， (6.18±1.22)， (4.63±1.37) and (2.48±1.19)， the difference was statistically significant (P<0.05). Conclusion Sufentanil combined with dextrozine is effective in the postoperative analgesia of patients with supraorbital mucosa. It is beneficial to reduce the pain level and promote the recovery of patients.
Key words：Supraorbital mucosal circumcision;Self-controlled analgesia;Sufentanil;Dizocine;Dose
痔是臨床上常见的肛门疾病，主要临床表现为肛门疼痛、瘙痒及间歇性便后出血等，给患者心理及生理均造成严重影响[1]。目前临床常采取手术治疗，痔上黏膜环切术利用吻合器环形切除，促使肛垫上移并固定，可有效达到治疗目，但术后患者易产生剧烈疼痛[2]。因此，给予科学合理的麻醉剂量，对缓解缓解术后疼痛，改善镇静效果具有重要作用。鉴于此，本研究进一步探讨痔上黏膜环切术后自控镇痛采取不同剂量舒芬太尼复合地佐辛对疼痛程度及镇静效果的影响，报道如下。, 百拇医药(张燕 王永娟)