绝经后妇女中骨质疏松患者血清钙磷、骨代谢指标与BMD的关系(1)
摘要：目的 探讨绝经后妇女骨质疏松患者血清钙磷、骨代谢指标与骨密度(BMD)的相关性。方法 应用双能X线吸收法对86例绝经后妇女进行骨密度检查，根据骨密度分为骨质疏松组63例和正常组23例。分别检测两组血清Ca、P、β-胶原降解产物(β-CrossLaps)、N端骨钙素(N-MID osteocalcin)、Ⅰ型胶原N端前肽(PⅠNP)指标，并进行比较。进一步根据年龄分为4组：≤59岁3例设为A组，60～69岁10例设为B组，70～79岁36例设为C组，≥80岁37例设为D组，分析各组骨代谢指标与BMD的相关性。结果 ①骨质疏松组的年龄为(78.21±7.57)岁，高于正常组的(74.35±7.15)岁，BMD低于正常组(P<0.01);②骨质疏松组β-CrossLaps、N-MID、PINP三项指标均高于正常组，但差异无统计学意义(P>0.05)，钙磷水平无明显差别(P>0.05);③β-CrossLaps在A组和C组与BMD呈负相关(r=-0.492、-0.035，P<0.05)，在B组和D组呈現正相关(r=0.318、0.058，P<0.05);N-MID在各组均与BMD呈负相关(r=-0.972、-0.382、-0.001、-0.153，P<0.05);PINP在C组与BMD呈正相关(r=0.052，P<0.05)，在A组、B组、D组与BMD呈负相关(r=-0.991、-0.515、-0.187，P<0.05);血清钙Ca在各组均与BMD呈正相关(r=0.362、0.307、0.105、0.137，P<0.05);P在A组、C组、D组与BMD呈负相关(r=-0.530、-0.047、-0.029，P<0.05)，而在B组与BMD呈正相关(r=0.020，P<0.05)。结论 β-CrossLaps、N-MID、PINP与BMD存在密切的关系，应联合用于骨质疏松症的诊治及病情监测。
, 百拇医药
关键词：骨质疏松症;骨代谢指标;骨密度
中图分类号：R681 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.001
文章编号：1006-1959(2019)04-0001-04
Abstract：Objective To investigate the correlation between serum calcium， phosphorus and bone metabolism markers and bone mineral density in postmenopausal women with osteoporosis. Methods A total of 86 postmenopausal women in our hospital were examined for bone mineral density by dual-energy X-ray absorptiometry. According to bone mineral density， 63 patients were divided into osteoporosis group and 23 patients in normal group. Serum Ca， P， β-collagen degradation products (β-CrossLaps)， N-terminal osteocalcin (N-MID) and type I collagen N-terminal propeptide (PINP) were measured and compared. According to the age， the patients were divided into 4 groups： ≤59 years old， 3 cases were set to group A， 60 to 69 years old， 10 cases were set to group B， 70 to 79 years old， 36 cases were set to group C， and ≥80 years old， 37 cases were set to group D. The correlation between bone metabolic markers and bone mineral density was analyzed. Results ①The age of osteoporosis group was (78.21±7.57) years old， higher than that of normal group (74±7.15) years old， bone mineral density was lower than normal group (P<0.01);②Osteoporosis group β-CrossLaps， N- MID and PINP were higher than the normal group， but the difference was not statistically significant (P>0.05). There was no significant difference in calcium and phosphorus levels (P>0.05). ③β-CrossLaps was negatively correlated with BMD in group A and C. (r=-0.492， -0.035， P<0.05)， there was a positive correlation between group B and group D (r=0.318， 0.058， P<0.05); N-MID was negatively correlated with BMD in each group (r= -0.972， -0.382， -0.001， -0.153， P<0.05); PINP was positively correlated with BMD in group C (r=0.052， P<0.05)， and negatively correlated with BMD in group A， B， and D ( r=-0.991， -0.515， -0.187， P<0.05); serum calcium was positively correlated with BMD in each group (r=0.362， 0.307， 0.105， 0.137， P<0.05); P in group A， group C， group D was negatively correlated with BMD (r=-0.530， -0.047， -0.029， P<0.05)， while there was a positive correlation between group B and BMD (r=0.020， P<0.05). Conclusion β-CrossLaps， N-MID， PINP and BMD are closely related and should be used in the diagnosis and treatment of osteoporosis and disease monitoring., 百拇医药(汪钦生 邵敏 姜涛)
, 百拇医药
关键词：骨质疏松症;骨代谢指标;骨密度
中图分类号：R681 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.001
文章编号：1006-1959(2019)04-0001-04
Abstract：Objective To investigate the correlation between serum calcium， phosphorus and bone metabolism markers and bone mineral density in postmenopausal women with osteoporosis. Methods A total of 86 postmenopausal women in our hospital were examined for bone mineral density by dual-energy X-ray absorptiometry. According to bone mineral density， 63 patients were divided into osteoporosis group and 23 patients in normal group. Serum Ca， P， β-collagen degradation products (β-CrossLaps)， N-terminal osteocalcin (N-MID) and type I collagen N-terminal propeptide (PINP) were measured and compared. According to the age， the patients were divided into 4 groups： ≤59 years old， 3 cases were set to group A， 60 to 69 years old， 10 cases were set to group B， 70 to 79 years old， 36 cases were set to group C， and ≥80 years old， 37 cases were set to group D. The correlation between bone metabolic markers and bone mineral density was analyzed. Results ①The age of osteoporosis group was (78.21±7.57) years old， higher than that of normal group (74±7.15) years old， bone mineral density was lower than normal group (P<0.01);②Osteoporosis group β-CrossLaps， N- MID and PINP were higher than the normal group， but the difference was not statistically significant (P>0.05). There was no significant difference in calcium and phosphorus levels (P>0.05). ③β-CrossLaps was negatively correlated with BMD in group A and C. (r=-0.492， -0.035， P<0.05)， there was a positive correlation between group B and group D (r=0.318， 0.058， P<0.05); N-MID was negatively correlated with BMD in each group (r= -0.972， -0.382， -0.001， -0.153， P<0.05); PINP was positively correlated with BMD in group C (r=0.052， P<0.05)， and negatively correlated with BMD in group A， B， and D ( r=-0.991， -0.515， -0.187， P<0.05); serum calcium was positively correlated with BMD in each group (r=0.362， 0.307， 0.105， 0.137， P<0.05); P in group A， group C， group D was negatively correlated with BMD (r=-0.530， -0.047， -0.029， P<0.05)， while there was a positive correlation between group B and BMD (r=0.020， P<0.05). Conclusion β-CrossLaps， N-MID， PINP and BMD are closely related and should be used in the diagnosis and treatment of osteoporosis and disease monitoring., 百拇医药(汪钦生 邵敏 姜涛)