不同剂量沐舒坦在肺癌围术期的肺功能保护作用(1)
摘 要：目的 探討不同剂量的沐舒坦在肺癌围术期的肺功能保护作用。方法 选取2015年1月～2017年1月在青岛大学附属医院胸外科进行手术治疗的90例非小细胞肺癌患者作为研究对象，随机分为小剂量组、中剂量组及大剂量组，每组30例。三组患者均在围手术期进行抗感染、营养支持等常规治疗的基础上，小剂量组给予沐舒坦200 mg/d持续静脉泵入，中剂量组给予沐舒坦500 mg/d持续静脉泵入，大剂量组给予沐舒坦800 mg/d持续静脉泵入，连续使用7 d后，比较三组患者术后肺部感染、肺不张等并发症发生率及术后1、3、5 d时的肺功能。结果 大剂量组患者的肺部感染率10.00%、肺不张发生率1.33%，低于中剂量组33.33%、66.67%，小剂量组53.33%、46.67%，三组差异有统计学意义(P<0.05)。术后第3、5天时大剂量组患者的PaO2、PaO2/FiO2高于中剂量组和小剂量组，三组差异有统计学意义(P<0.05)。结论 大剂量的沐舒坦在肺癌围手术期的肺功能保护作用优于中剂量、小剂量，中剂量的沐舒坦在肺癌围手术期的肺功能保护作用优于小剂量，即大剂量沐舒坦有助于降低肺部并发症，改善肺癌患者预后。
, 百拇医药
关键词：不同剂量；沐舒坦；肺癌围术期；肺功能保护
中图分类号：R734.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.07.043
文章编号：1006-1959(2018)07-0128-03
Protective Effects of Different Doses of Ambroxol on Lung Function in Patients with Lung Cancer during Perioperative Period
LI Feng-li1，CHEN Wei2，ZHANG Lin3
(1.Qingdao University，Qingdao 266003，Shandong，China；
, http://www.100md.com
2.Department of Neurosurgery，Linyi Central Hospital，Linyi 276400，Shandong，China；
3.Department of Anesthesiology，Affiliated Hospital of Qingdao University，Qingdao 266555，Shandong，China)
Abstract：Objective To investigate the protective effect of different doses of ambroxol on lung function in lung cancer perioperative period.Methods From January 2015 to January 2017，90 patients with non-small cell lung cancer(NSCLC)were randomly divided into three groups：small dose group，middle dose group and high dose group，30 cases in each group.All patients in the three groups were treated on the basis of routine treatment such as anti-infection and nutritional support during the perioperative period.In the low-dose group， continuous infusion of moxatan 200 mg/d was continued，and in the middle-dose group， mucosolvan 500 mg/d was continuously intravenously pumped.Large dose group received ambroxol 800 mg/d continuous intravenous infusion.After continuous use for 7 d，the incidence of postoperative complications such as pulmonary infection，atelectasis and lung function at 1，3，5 d after operation were compared between the three groups.Results The high-dose group had a pulmonary infection rate of 10.00% and a lung atelectasis rate of 1.33%，which was lower than the middle-dose group 33.33%，66.67% and the low-dose group 53.33%，46.67%，the difference between the three groups was statistically significant(P<0.05).At third，fifth days after the operation，the PaO2 and PaO2/FiO2 in the large dose group were higher than those in the middle dose group and the small dose group，and the difference between the three groups was statistically significant(P<0.05).Conclusion The protective effect of high dose ambroxol on lung function in lung cancer perioperative period was superior to that of middle dose，low dose，middle dose ambroxol was superior to small dose in lung cancer perioperative period.That is，high dose ambroxol can reduce pulmonary complications and improve the prognosis of lung cancer patients., 百拇医药(李凤利 陈伟 张林)
, 百拇医药
关键词：不同剂量；沐舒坦；肺癌围术期；肺功能保护
中图分类号：R734.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.07.043
文章编号：1006-1959(2018)07-0128-03
Protective Effects of Different Doses of Ambroxol on Lung Function in Patients with Lung Cancer during Perioperative Period
LI Feng-li1，CHEN Wei2，ZHANG Lin3
(1.Qingdao University，Qingdao 266003，Shandong，China；
, http://www.100md.com
2.Department of Neurosurgery，Linyi Central Hospital，Linyi 276400，Shandong，China；
3.Department of Anesthesiology，Affiliated Hospital of Qingdao University，Qingdao 266555，Shandong，China)
Abstract：Objective To investigate the protective effect of different doses of ambroxol on lung function in lung cancer perioperative period.Methods From January 2015 to January 2017，90 patients with non-small cell lung cancer(NSCLC)were randomly divided into three groups：small dose group，middle dose group and high dose group，30 cases in each group.All patients in the three groups were treated on the basis of routine treatment such as anti-infection and nutritional support during the perioperative period.In the low-dose group， continuous infusion of moxatan 200 mg/d was continued，and in the middle-dose group， mucosolvan 500 mg/d was continuously intravenously pumped.Large dose group received ambroxol 800 mg/d continuous intravenous infusion.After continuous use for 7 d，the incidence of postoperative complications such as pulmonary infection，atelectasis and lung function at 1，3，5 d after operation were compared between the three groups.Results The high-dose group had a pulmonary infection rate of 10.00% and a lung atelectasis rate of 1.33%，which was lower than the middle-dose group 33.33%，66.67% and the low-dose group 53.33%，46.67%，the difference between the three groups was statistically significant(P<0.05).At third，fifth days after the operation，the PaO2 and PaO2/FiO2 in the large dose group were higher than those in the middle dose group and the small dose group，and the difference between the three groups was statistically significant(P<0.05).Conclusion The protective effect of high dose ambroxol on lung function in lung cancer perioperative period was superior to that of middle dose，low dose，middle dose ambroxol was superior to small dose in lung cancer perioperative period.That is，high dose ambroxol can reduce pulmonary complications and improve the prognosis of lung cancer patients., 百拇医药(李凤利 陈伟 张林)