抗体介导肝靶向抗肿瘤给药系统的研究进展(4)
[24] ZHOU Y，DRUMMOND DC，ZOU H，et al. Impact of single chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor expressing tumor cells[J]. J Mol Biol，2007，371(4)：934-947.
[25] GUNAWAN RC，AUGUSTE DT. The role of antibody sy- nergy and membrane fluidity in the vascular targeting of immunoliposomes[J]. Biomaterials，2010，31(5)：900-907.
[26] SAUL JM，ANNAPRAGADA AV，BELLAMKONDA RV. A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers[J]. J Control Release，2006，114(3)：277-287.
[27] GAO J，CHEN H，YU Y，et al. Inhibition of hepatocellular carcinoma growth using immunoliposomes for co-delivery of adriamycin and ribonucleotide reductase M2 siRNA[J]. Biomaterials，2013，34(38)：10084-10098.
[28] CHEN L，LIU YH，LI YH，et al. Anti-hepatoma human single-chain Fv antibody and adriamycin conjugates with potent antitumor activity[J]. Int Immunopharmacol，2014，18(1)：20-26.
[29] LI J，ZHOU P，LI L，et al. Effects of cationic microbubble carrying CD/TK double suicide gene and αVβ3 integrin antibody in human hepatocellular carcinoma HepG2 cells[J]. PLoS One，2016，11(7)：e0158592.
(收稿日期：2017-05-10 修回日期：2017-11-06)
(編辑：余庆华), 百拇医药(王丹丹 朱静 张玮 吴卫)
[25] GUNAWAN RC，AUGUSTE DT. The role of antibody sy- nergy and membrane fluidity in the vascular targeting of immunoliposomes[J]. Biomaterials，2010，31(5)：900-907.
[26] SAUL JM，ANNAPRAGADA AV，BELLAMKONDA RV. A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers[J]. J Control Release，2006，114(3)：277-287.
[27] GAO J，CHEN H，YU Y，et al. Inhibition of hepatocellular carcinoma growth using immunoliposomes for co-delivery of adriamycin and ribonucleotide reductase M2 siRNA[J]. Biomaterials，2013，34(38)：10084-10098.
[28] CHEN L，LIU YH，LI YH，et al. Anti-hepatoma human single-chain Fv antibody and adriamycin conjugates with potent antitumor activity[J]. Int Immunopharmacol，2014，18(1)：20-26.
[29] LI J，ZHOU P，LI L，et al. Effects of cationic microbubble carrying CD/TK double suicide gene and αVβ3 integrin antibody in human hepatocellular carcinoma HepG2 cells[J]. PLoS One，2016，11(7)：e0158592.
(收稿日期：2017-05-10 修回日期：2017-11-06)
(編辑：余庆华), 百拇医药(王丹丹 朱静 张玮 吴卫)