NPY/AgRP与肥胖及其相关疾病研究进展(3)
[4] Hirsch D， Zukowska Z. NPY and stress 30 years later： the peripheral view. Cell Mol Neurobiol，2012，32(5)：645-659.
[5] B?ckberg M， Madjid N， Ogren SO， Meister B. Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice. Brain Res Mol Brain Res，2004，125(1-2)：129-139.
[6] Ollmann MM， Wilson BD， Yang YK， Kerns JA， Chen Y， Gantz I， Barsh GS. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science，1997，278(5335)：135-138.
, 百拇医药
[7] 賈敏，贺媛，张晓辉，张淑苗，李娟，顾晓明，王跃民，樊荣，裴建明 .肥胖相关性神经肽Y研究现状.神经解剖学杂志， 2017， 33 (1) ：107-110.
[8] Atasoy D， Betley JN， Su HH， Sternson SM. Deconstruction of a neural circuit for hunger. Nature，2012，488(7410)：172-177.
[9] Teubner BJ， Keen-Rhinehart E， Bartness TJ. Third ventricular coinjection of subthreshold doses of NPY and AgRP stimulate food hoarding and intake and neural activation. Am J Physiol Regul Integr Comp Physiol，2012，302(1)：R37-R48.
, 百拇医药
[10] Krashes MJ， Shah BP， Koda S， Lowell BB. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA， NPY， and AgRP. Cell Metab，2013，18(4)：588-595.
[11] Day DE， Keen-Rhinehart E， Bartness TJ. Role of NPY and its receptor subtypes in foraging， food hoarding， and food intake by Siberian hamsters. Am J Physiol Regul Integr Comp Physiol， 2005，289(1)：R29-R36.
[12] Bo E， Farinetti A， Marraudino M， Sterchele D， Eva C， Gotti S， Panzica G. Adult exposure to tributyltin affects hypothalamic neuropeptide Y， Y1 receptor distribution， and circulating leptin in mice. Andrology，2016，4(4)：723-734.
, http://www.100md.com
[13] Coppari R， Ichinose M， Lee CE， Pullen AE， Kenny CD， McGovern RA， Tang V， Liu SM， Ludwig T. Chua SC Jr， Lowell BB， Elmquist JK. The hypothalamic arcuate nucleus： a key site for mediating leptin’s effects on glucose homeostasis and locomotor activity. Cell Metab，2005，1(1)：63-72.
[14] Abe M， Saito M， Ikeda H， Shimazu T. Increased neuropeptide Y content in the arcuato-paraventricular hypothalamic neuronal system in both insulin-dependent and non-insulin-dependent diabetic rats. Brain Res，1991，539(2)：223-227.
[15] Long M， Zhou J， Li D， Zheng L， Xu Z， Zhou S. Long-term over-expression of neuropeptide Y in hypothalamic paraventricular nucleus contributes to adipose tissue insulin resistance partly via the Y5 receptor. PLoS One，2015，10(5)：e0126714.
(收稿日期：2018-11-10)
(本文编辑：洪悦民), 百拇医药(于璐 宋海燕)
[5] B?ckberg M， Madjid N， Ogren SO， Meister B. Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice. Brain Res Mol Brain Res，2004，125(1-2)：129-139.
[6] Ollmann MM， Wilson BD， Yang YK， Kerns JA， Chen Y， Gantz I， Barsh GS. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science，1997，278(5335)：135-138.
, 百拇医药
[7] 賈敏，贺媛，张晓辉，张淑苗，李娟，顾晓明，王跃民，樊荣，裴建明 .肥胖相关性神经肽Y研究现状.神经解剖学杂志， 2017， 33 (1) ：107-110.
[8] Atasoy D， Betley JN， Su HH， Sternson SM. Deconstruction of a neural circuit for hunger. Nature，2012，488(7410)：172-177.
[9] Teubner BJ， Keen-Rhinehart E， Bartness TJ. Third ventricular coinjection of subthreshold doses of NPY and AgRP stimulate food hoarding and intake and neural activation. Am J Physiol Regul Integr Comp Physiol，2012，302(1)：R37-R48.
, 百拇医药
[10] Krashes MJ， Shah BP， Koda S， Lowell BB. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA， NPY， and AgRP. Cell Metab，2013，18(4)：588-595.
[11] Day DE， Keen-Rhinehart E， Bartness TJ. Role of NPY and its receptor subtypes in foraging， food hoarding， and food intake by Siberian hamsters. Am J Physiol Regul Integr Comp Physiol， 2005，289(1)：R29-R36.
[12] Bo E， Farinetti A， Marraudino M， Sterchele D， Eva C， Gotti S， Panzica G. Adult exposure to tributyltin affects hypothalamic neuropeptide Y， Y1 receptor distribution， and circulating leptin in mice. Andrology，2016，4(4)：723-734.
, http://www.100md.com
[13] Coppari R， Ichinose M， Lee CE， Pullen AE， Kenny CD， McGovern RA， Tang V， Liu SM， Ludwig T. Chua SC Jr， Lowell BB， Elmquist JK. The hypothalamic arcuate nucleus： a key site for mediating leptin’s effects on glucose homeostasis and locomotor activity. Cell Metab，2005，1(1)：63-72.
[14] Abe M， Saito M， Ikeda H， Shimazu T. Increased neuropeptide Y content in the arcuato-paraventricular hypothalamic neuronal system in both insulin-dependent and non-insulin-dependent diabetic rats. Brain Res，1991，539(2)：223-227.
[15] Long M， Zhou J， Li D， Zheng L， Xu Z， Zhou S. Long-term over-expression of neuropeptide Y in hypothalamic paraventricular nucleus contributes to adipose tissue insulin resistance partly via the Y5 receptor. PLoS One，2015，10(5)：e0126714.
(收稿日期：2018-11-10)
(本文编辑：洪悦民), 百拇医药(于璐 宋海燕)