双歧杆菌DNA;_巨噬细胞;_蛋白激酶C;

双歧杆菌DNA对小鼠巨噬细胞中PKC和NFκB的影响

http://www.100md.com 《细胞与分子免疫学杂志》 2007年第1期

双歧杆菌DNA;,巨噬细胞;,蛋白激酶C;,核因子κB,,\]双歧杆菌DNA;,巨噬细胞;,蛋白激酶C;,核因子κB,\[关键词\]双歧杆菌DNA;巨噬细胞;蛋白激酶C;核因子κB,1材料和方法,2结果,3讨论,参考文献:

     Influence of bifidobacterium DNA on PKC and NFκB in murine macrophages

    WANG Lisheng1, LI Yingxue1, ZHU Huiming1, ZHU Zhongsheng1, MA Xiaodong2

    1Department of Gastroenterology, the Second Clinical Medical Hospital, Jinan University, Shenzhen 518020; 2Center Laboratory, Nanfang Medical University, Guangzhou 510515, China

    \[Abstract\] AIM: To explore the influence of DNA of bifidobacteriua adolescence on PKC and NKκB of murine macrophages. METHODS: The fluorescent intensity of PKCα、 PKCβI、 PKCβII、 PKCγ、 PKCε and PKCζ in murine peritoneal macrophages was detected by using laser confocal microscope. The density of NKκB+ macrophages was detected by immunocytochemical staining. RESULTS: The average fluorescent intensity of PKCα and PKCβII produced by mouse peritoneal macrophages in bifidobacterium DNA injection group was markedly higher than that in control group(P<0.01). There was no statistically significant difference of average fluorescent intensity of PKCβI、 PKCγ、 PKCε and PKCζ between the two groups(P>0.05). The density of NKκB+ macrophages in bifidobacterium DNA injection group was markedly higher than that in control group(P<0.01). CONCLUSION: DNA of bifidobacteria adolescence could activate macrophages by promoting the activity of PKCα、 PKCβII and NFκB. ......

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