摘要:目的 探讨病毒性肝炎患者血清白细胞介素-6(IL-6)和肿瘤坏死因子(TNF-α)的浓度变化及其临床意义。 方法 对30例健康体检者和50例病毒性肝炎患者的血清采用放射免疫分析(RIA)测定IL-6和TNF-α的浓度，同期检测其HBV DNA。 结果 病毒性肝炎患者的IL-6和TNF-α水平显著高于正常对照组(P<0.01)。肝炎后肝硬化组显著高于慢性乙型肝炎组(P<0.01)，HBV DNA阳性组显著高于HBV DNA阴性组(P<0.01)。 结论 病毒性肝炎患者IL-6和TNF-α的测定能反映机体免疫损伤状况，对判断患者病情和预后有一定的临床价值。

    关键词:白细胞介素-6;肿瘤坏死因子;病毒性肝炎

    The detection of interferon-6and tumor necrosis factor-αand their clinical significance in the patients with chronic hepatitis B.

    LIUJun-feng，JUPing.

    (Laboratory Department of Huangshi Municipal Second People's Hospital，Huangshi435002，Hubei，P.R.China)

    Abstract:Objective To investigate the concentration and its clinical significance of serum Interleukin-6(IL-6)and Tumor Necrosis Factorα(TNF-α)in the patients with chronic viral hepatitis B. Methods Serum IL-6and TNF-αin30healthy per-son and50patients with chronic viral hepatitis B were determined by radioimmunoassay(RIA).In addition ......