[摘要] 目的 探讨血清胰岛素样生长因子(IGF-1)水平与摄131I率在甲状腺结节诊断中的意义。方法 采用放射免疫分析法(RIA)检测单纯性甲状腺温热结节患者、冷凉结节患者各30例，同时从我院健康体检的人群中选择与试验组年龄、性别相匹配的30例作为对照组。所有受试者均检测IGF-1及甲状腺功能，包括FT3、FT4、sTSH以及131I摄取率。所得结果进行统计学分析。结果 与对照组比较,温热结节组血清IGF-1及FT3、FT4明显升高,131I摄取率也明显增高，sTSH显著降低(均P<0.01)。冷凉结节组与对照组差异无显著性。结论 单纯性温热结节甲状腺肿患者血清中IGF-1的浓度与血清中131I摄取率水平呈正相关,与sTSH呈负相关。

    [关键词] 单纯性甲状腺肿；胰岛素样生长因子-1；131I摄取率；甲状腺激素

    Study on relation between insulin like growth factor-1 and simple goiter

    SONG Guang-jie,LIU Jin-jun,YU Xue-qing.Department of The Second Surgery,The First Hospital of Zhangjiakou,Zhangjiakou 075000,China

    [Abstract] Objective To investigate the diagnostic value of insulin line growth factor-1 ( IGF-1) and 131I uptake rate in the simple nodular goiter.Methods The serum FT3,FT4,sTSH,IGF-1 levels were determined by radioimmunoprecipitation assay(RIA) in 60 cases of simple goiter patients,30 of them were warm-hot nodule patients,another 30 cold-cool nodule patients.In the same time,the sex and age were matched with the normal of the control group.All sample detected serum IGF-1 and thyroid factions.The results deal with statistics.Results In contrast,the levels of serum IGF-1,FT3,FT4.The 131I uptake rate markedly increased and serum sTSH markedly decreased in the warm-hot nodule simple goiter group.There were no obvious differences between cold-cool nodule group and controls.Conclusion Serum IGF-1 is positive relation with 131I uptake rate and negative relation with serum sTSH in the simple nodular goiter. ......