药物性肝损害；结核；复方甘草酸苷_

复方甘草酸苷在HBsAg阳性结核患者发生药物性肝损害中的防治作用

http://www.100md.com 《汕头大学医学院学报》 2006年第2期

药物性肝损害；结核；复方甘草酸苷,,]药物性肝损害；结核；复方甘草酸苷,1资料与方法,2结果,3讨论,参考文献：

     [摘要]目的：探讨复方甘草酸苷在HBsAg阳性结核患者发生药物性肝损害中的防治作用。方法：56例HBsAg阳性结核患者分为治疗组[在抗结核病药物的基础上加用复方甘草酸苷注射液60～80mL，静滴1次/d]和对照组[在抗结核药物的基础上加用肝泰乐注射液4mL，静滴1次/d]。对两组发生肝损害的情况进行比较。结果：治疗组药物性肝损害5例(179%)，对照组15例(536%)；治疗组肝损害程度低于对照组(P<001)。结论：复方甘草酸苷可显著降低药物性肝损害的发生。

    [关键词]药物性肝损害；结核；复方甘草酸苷

    Prevention and Treatment Effect of Compound Glycyrrhizin in 56 HBsAg PositivePatients with Tuberculosis

    SUN Peng, LIe, QIU Jie_wen, CAI Miao_ling

    (1Department of Infectious Diseases, The Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China;2Department of Infectious Diseases, The First Affiliated Hospital, Shantou University Medical College, Shantou515041, China)

    [Abstract]Objective: To explore the prevention and treatment effect of compound glycyrrhizin in 56 HBsAg positive patients with tuberculosis. Methods: Fifty_six HBsAg positive patients with tuberculosis were divided into treatment group(compound glycyrrhizin injection from 60 to 80 mL by intravenous drip, once a day on the basis of given anti_tuberculosis medicine)and control group(glucurolactone injection 03g by intravenous drip, once a day on the basis of given anti_tuberculosis medicine). The liver damage level between two groups was compared. Results: There were 5 cases who had liver damage in treatment group(179%)and 15 cases in control group(536%). The liver damage level in treatment group was lower than in control group(P<001). Conclusion: Compound glycyrrhizin can evidently reduce the drug_induced liver damage. ......

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