气相色谱法测定依达拉奉合成原料乙酰乙酸乙酯中的丙酮溶剂残留
气相色谱法,,],气相色谱法；依达拉奉乙酰乙酸乙酯；丙酮；残留量,1仪器与试药,2实验方法,3结果,4讨论,参考文献：
[摘要] 目的：用气相色谱法测定依达拉奉合成起始原料乙酰乙酸乙酯中丙酮的残留量。方法：采用固定相为二乙烯苯乙基乙烯苯型高分子多孔小球(直径为0.18 mm～0.25 mm)，氮气为载气， 用外标法测定乙酰乙酸乙酯中残留丙酮的含量。结果：该方法在丙酮浓度范围在25 μg/ml～400 μg/ml内呈良好的线性关系，响应曲线相关系数为0.996，平均回收率为96.8%。结论：本法简便，快速、实用，灵敏度高，可有效地用于乙酰乙酸乙酯的质量控制。[关键词] 气相色谱法；依达拉奉乙酰乙酸乙酯；丙酮；残留量
Determination of Residual Acetone in Acetoacetic Ester (the raw Material for the Synthesis of Edaravone) by Gas Chromatography
WU Huazhen
(Guangdong Provincial People's Hospital, Guangzhou, Guangdong 510080, China)
Abstract：Objective To determine the contents of residual acetone in acetoacetic ester,the raw material for the synthesis of Edaravone, by gas chromatography.Methods Sample solution was injected on a GDX column (0.18 mm～0.25 mm) with nitrogen as the carrier gas.The residue was calculated by the external standard method.Results The linearity was good over the range of 25 μg/ml～400 μg/ml,with the correlation coefficient of acetone being 0.996 and the average recovery 96.8%.Conclusions The method was proved to be simple,rapid,practical and highly sensitive.It is an efficient method for the quality control of acetoacetic ester. ......
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