热疗临床应用进展.PDF
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5 Sheng H , Williams CS , Shao J , et al . Induction of cyclooxygenase2
2 by activated Ha2ras oncogene in Rat21 fibroblasts and the role of
mitogen2activated protein kinase pathway. J Biol Chem , 1998 ,273
(34) : 22120222127.
6 Sheng H , Shao J , Dixon DA , et al . Transforming growth factor2be2
ta1 enhances Ha2ras2induced expression of cyclooxygenase22 in intes2
tinal epithelial cells via stabilization of mRNA. J Biol Chem , 2000 ,275 (9) : 662826635.
7 Sheng H , Shao J , Dubois RN. K 2Ras2mediated increase in cycloox2
ygenase 2 mRNA stability involves activation of the protein kinase
B1. Cancer Res , 2001 , 61 (6) : 267022675.
8 Leng J , Han C , Demet ris AJ , et al . Cyclooxygenase22 promotes
hepatocellular carcinoma cell growth through Akt activation : evi2
dence for Akt inhibition in celecoxib2induced apoptosis. Hepatology ,2003 , 38 (3) : 7562768.
9 Chan TA , Morin PJ , Vogelstein B , et al . Mechanisms underlying
nonsteroidal antiinflammatory drug2mediated apoptosis. Proc Natl
Acad Sci USA , 1998 , 95 (2) : 6812686.
10 Tsujii M , Kawano S , Tsuji S , et al . Cyclooxygenase regulates an2
giogenesis induced by colon cancer cells. Cell , 1998 , 93 (5) : 7052
716.
11 Ramalingam S , Belani CP. Cyclooxygenase22 inhibitors in lung
cancer . Clin Lung Cancer , 2004 ,5 (4) : 2452253.
12 Masferrer JL , Leahy KM , Koki AT , et al . Antiangiogenic and an2
titumor activities of cyclooxygenase22 inhibitors. Cancer Res ,2000 , 60 (5) : 130621311.
13 Zachary I. Signaling mechanisms mediating vascular protective ac2
tions of vascular endothelial growth factor . AmJ Physiol Cell Phys2
iol , 2001 , 280 (6) : C137521386.
14 Nie D , Lamberti M , Zacharek A ,et al . Thromboxane A(2) regu2
lation of endothelial cell migration , angiogenesis , and tumor metas2
tasis. Biochem Biophys Res Commun , 2000 , 267 (1) : 2452251.
15 Tsujii M , Kawano S , DuBois RN. Cyclooxygenase22 expression in
human colon cancer cells increases metastatic potential . Proc Natl
Acad Sci USA , 1997 , 94 (7) : 333623340.
16 Dohadwala M , Luo J , Zhu L , et al . Non2small cell lung cancer cy2
clooxygenase 222dependent invasion is mediated by CD44. J Biol
Chem , 2001 , 276 (24) : 20809220812.
17 Okami J , Nakamori S , Hiraoka N , et al . Suppression of pancreatic
cancer cell invasion by a cyclooxygenase222specific inhibitor . Clin
Exp Metastasis , 2003 , 20 (7) : 5772584.
18 Wick M , Hurteau G, Dessev C , et al . Peroxisome proliferator2ac2
tivated receptor2gamma is a target of nonsteroidal anti2inflammatory
drugs mediating cyclooxygenase2independent inhibition of lung can2
cer cell growth. Mol Pharmacol , 2002 , 62 (5) : 120721214.
19 He TC , Chan TA , Vogelstein B , et al . PPARdelta is an APC2reg2
ulated target of nonsteroidal anti2inflammatory drugs. Cell , 1999 ,99 (3) : 3352345.
20 Elder DJ , Halton DE , Playle LC , et al . The MEK P ERK pathway
mediates COX222selective NSAID2induced apoptosis and induced
COX22 protein expression in colorectal carcinoma cells. Int J Can2
cer , 2002 , 99 (3) : 3232327.
21 Ost rowski J , Wocial T , Skurzak H , et al . Do altering in ornithine
decarboxylase activity and gene expression cont ribute to antiprolife2
rative properties of COX inhibitors ? Br J Cancer , 2003 , 88 (7) :
114321151.
(收稿日期:2003211229 修回日期:2004203220)
作者单位: 300060 天津医科大学附属肿瘤医院放疗科
热疗临床应用进展
陈忠杰综述 朱莉 王平审校
摘要 热疗联合手术、放疗和化疗等综合治疗能明显降低恶性肿瘤局部复发率 ,提高患者生存
率 ,改善生活质量 ,且不增加术后并发症 ......
2 by activated Ha2ras oncogene in Rat21 fibroblasts and the role of
mitogen2activated protein kinase pathway. J Biol Chem , 1998 ,273
(34) : 22120222127.
6 Sheng H , Shao J , Dixon DA , et al . Transforming growth factor2be2
ta1 enhances Ha2ras2induced expression of cyclooxygenase22 in intes2
tinal epithelial cells via stabilization of mRNA. J Biol Chem , 2000 ,275 (9) : 662826635.
7 Sheng H , Shao J , Dubois RN. K 2Ras2mediated increase in cycloox2
ygenase 2 mRNA stability involves activation of the protein kinase
B1. Cancer Res , 2001 , 61 (6) : 267022675.
8 Leng J , Han C , Demet ris AJ , et al . Cyclooxygenase22 promotes
hepatocellular carcinoma cell growth through Akt activation : evi2
dence for Akt inhibition in celecoxib2induced apoptosis. Hepatology ,2003 , 38 (3) : 7562768.
9 Chan TA , Morin PJ , Vogelstein B , et al . Mechanisms underlying
nonsteroidal antiinflammatory drug2mediated apoptosis. Proc Natl
Acad Sci USA , 1998 , 95 (2) : 6812686.
10 Tsujii M , Kawano S , Tsuji S , et al . Cyclooxygenase regulates an2
giogenesis induced by colon cancer cells. Cell , 1998 , 93 (5) : 7052
716.
11 Ramalingam S , Belani CP. Cyclooxygenase22 inhibitors in lung
cancer . Clin Lung Cancer , 2004 ,5 (4) : 2452253.
12 Masferrer JL , Leahy KM , Koki AT , et al . Antiangiogenic and an2
titumor activities of cyclooxygenase22 inhibitors. Cancer Res ,2000 , 60 (5) : 130621311.
13 Zachary I. Signaling mechanisms mediating vascular protective ac2
tions of vascular endothelial growth factor . AmJ Physiol Cell Phys2
iol , 2001 , 280 (6) : C137521386.
14 Nie D , Lamberti M , Zacharek A ,et al . Thromboxane A(2) regu2
lation of endothelial cell migration , angiogenesis , and tumor metas2
tasis. Biochem Biophys Res Commun , 2000 , 267 (1) : 2452251.
15 Tsujii M , Kawano S , DuBois RN. Cyclooxygenase22 expression in
human colon cancer cells increases metastatic potential . Proc Natl
Acad Sci USA , 1997 , 94 (7) : 333623340.
16 Dohadwala M , Luo J , Zhu L , et al . Non2small cell lung cancer cy2
clooxygenase 222dependent invasion is mediated by CD44. J Biol
Chem , 2001 , 276 (24) : 20809220812.
17 Okami J , Nakamori S , Hiraoka N , et al . Suppression of pancreatic
cancer cell invasion by a cyclooxygenase222specific inhibitor . Clin
Exp Metastasis , 2003 , 20 (7) : 5772584.
18 Wick M , Hurteau G, Dessev C , et al . Peroxisome proliferator2ac2
tivated receptor2gamma is a target of nonsteroidal anti2inflammatory
drugs mediating cyclooxygenase2independent inhibition of lung can2
cer cell growth. Mol Pharmacol , 2002 , 62 (5) : 120721214.
19 He TC , Chan TA , Vogelstein B , et al . PPARdelta is an APC2reg2
ulated target of nonsteroidal anti2inflammatory drugs. Cell , 1999 ,99 (3) : 3352345.
20 Elder DJ , Halton DE , Playle LC , et al . The MEK P ERK pathway
mediates COX222selective NSAID2induced apoptosis and induced
COX22 protein expression in colorectal carcinoma cells. Int J Can2
cer , 2002 , 99 (3) : 3232327.
21 Ost rowski J , Wocial T , Skurzak H , et al . Do altering in ornithine
decarboxylase activity and gene expression cont ribute to antiprolife2
rative properties of COX inhibitors ? Br J Cancer , 2003 , 88 (7) :
114321151.
(收稿日期:2003211229 修回日期:2004203220)
作者单位: 300060 天津医科大学附属肿瘤医院放疗科
热疗临床应用进展
陈忠杰综述 朱莉 王平审校
摘要 热疗联合手术、放疗和化疗等综合治疗能明显降低恶性肿瘤局部复发率 ,提高患者生存
率 ,改善生活质量 ,且不增加术后并发症 ......
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