长期拉米夫定治疗无效慢性乙肝患者 106 例
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杨守平, 胡德昌, 胡锡琪, 郑可飞
慢性乙型肝炎;治疗无效;拉米夫定,长期拉米夫定治疗无效慢性乙肝患者106例,杨守平,郑可飞,胡德昌,通讯作者:,Long-termineffectivetreatmentofchronichepa
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杨守平, 郑可飞, 乐清市第三人民医院中西医结合肝病科 浙江省乐清市 325604
胡德昌, 复旦大学附属中山医院消化科 上海市 200032
胡锡琪, 复旦大学医学院病理系 上海市 200032
通讯作者: 杨守平, 325604, 浙江省乐清市柳市前市街335号, 乐清市第三人民医院中西医结合肝病科. weiyu1966@126.com
电话: 0577-82173698 传真: 0577-62782169
收稿日期: 2005-12-12 接受日期: 2005-12-31
Long-term ineffective treatment of chronic hepatitis B with Lamivudine: an analysis of 106 cases
Shou-Ping Yang, De-Chang Hu, Xi-Qi Hu, Ke-Fei Zheng
Shou-Ping Yang, Ke-Fei Zheng, Department of Integrated Traditional Chinese Medicine and Western Medicine for Liver Disease, the Third Municipal People’s Hospital, Yueqing 325604, Zhejiang Province, China
De-Chang Hu, Department of Gastroenterology, the Affiliated Zhongshan Hospital of Fudan University, Shanghai 200032, China
Xi-Qi Hu, Department of Pathology, the Affiliated Zhongshan Hospital of Fudan University, Shanghai 200032, China
Correspondence to: Shou-Ping Yang, Department of Integrated Traditional Chinese Medicine and Western Medicine for Liver Disease, the Third Municipal People’s Hospital, Yueqing 325604, Zhejiang Province, China. weiyu@126.com
Received: 2005-12-12 Accepted: 2005-12-31
Abstract
AIM: To summarize the valuable experiences through analysis of long-term ineffective treatm-ent with Lamivudine (LAM) on chronic hepatitis B patients.
METHODS: One hundred and six patients, with or without early-stage cirrhosis, were followed up and the clinical data retrospectively analyzed. All the patients were observed in terms of clinical manifestations and received tests of liver function, hepatitis B virus markers and YMDD mutations. Of these patients, 17 also received CD cell examination, and 43 received liver biopsies.
RESULTS: The percentages of elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were 100% (106/106) and 92.5% (98/106), respectively. All the 106 patients were HBsAg-positive, and 104 were HBeAg-positive while 2 were HBeAb-positive ......
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