[摘 要] 目的 观察托烷司琼对异丙酚静脉注射引起的疼痛缓解程度，与利多卡因和安慰剂对照比较。 方法 选择124例ASA I～Ⅱ级的择期手术病人，随机分为4组:对照组(异丙酚+生理盐水)，I组(异丙酚+利多卡因40mg)，Ⅱ组(异丙酚+托烷司琼2mg)，Ⅲ组(异丙酚+托烷司琼4mg)，所有药物均配成4ml液体，观察每组疼痛的发生率和程度。 结果 与对照组相比较，托烷司琼和利多卡因一样可以明显降低异丙酚静脉注射疼痛发生率，托烷司琼2mg与利多卡因40mg效果无显著差异，而托烷司琼4mg减轻静脉注射痛效果最好。 结论 在异丙酚注射之前60s，利多卡因40mg，托烷司琼2mg，托烷司琼4mg的缓慢注射均可降低异丙酚静脉注射痛的发生率，而托烷司琼4mg效果最佳。

    [关键词] 托烷司琼;利多卡因;疼痛;异丙酚

    Prevention of tropisetron for pain associated with propofol injection

    ZHOU Rong，LIU Feng

    Operating Room，Institute of Surgery Research，Daping Hospital，Third Military Medical University，Chongqing400038，China

    Abstract:Objective To compare the efficacy of tropisetron intravenous injeciton at the dose of2mg and4mg，lidocaine of40mg and place-bo in preventing the pain due to intravenous propofol administration.Methods A total of124patients scheduled for elective surgery were randomly divided into four groups.GroupⅠreceived0.9%saline(4ml) ......