关键词: 地塞米松;苯巴比妥钠;利多卡因;肝P4503A酶;小鼠

    摘 要:目的 研究地塞米松、苯巴比妥钠和利多卡因预处理的昆明种小鼠P4503A酶有无诱导作用及其作用机制. 方法 给昆明种小鼠腹腔注射常用量地塞米松、苯巴比妥钠或利多卡因1wk后，观察MEGX累积排泄量、P4503A酶蛋白含量及其mRNA表达的改变. 结果 与正常对照组相比，地塞米松组小鼠MEGX累积排泄量增加35.0%(P<0.05)，P4503A酶蛋白含量增加147.1%(P<0.01);苯巴比妥钠小鼠MEGX累积排泄量增加23.4%(P<0.05)，酶蛋白含量增加43.6%(P<0.01);各组间P4503A酶mRNA表达无明显差别. 结论 地塞米松和苯巴比妥钠对昆明种小鼠肝P4503A酶有诱导作用，该作用位于转录后水平;利多卡因对昆明种小鼠肝P4503A酶无影响.

    Effect of dexamethasone，phenobarbital and lido┐caine on hepatic P4503A enzyme in Kunming mice

    LI Ping1 ，CHENG Jian-Feng1 ，CHEN Dong-Hong1 ，HE Jian-Rong1 ，TENG Shuo-Bao1 ，ZHONG Chong-Hua1 ，DIAO Ya-Ying1 ，HE Ping2

    1 Department of Pharmacy，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China，

    2 Dongfang Institute of Hepatobiliary Surgery，Second Military Medical University，Shanghai200438，China

    Keywords:dexamethasone;phenobarbital;lidocaine;hepatic P4503A enzyme;mice

    Abstract:AIM To study the induction of dexamethasone，phenobarbital and lidocaine on hepatic P4503A enzyme in Kunming mice.METHODS After administering ip a non-toxic dose of dexamethasone，phenobarbital or lidocaine to Kunming mice for7d ......