关键词: 食管;肿瘤;分子流行病学;西安地区

    摘 要:目的 探讨西安地区食管癌与p53和H-Ras高表达的关系. 方法 应用分子流行病学研究方法，调查分析了西安地区61例病例、43例对照的基础资料并检测组织中p53和H-Ras高表达情况. 结果 病例组p53和H-Ras的高表达率(分别为80.3%，41.0%)均高于对照组(30.2%，16.3%，P<0.01).p53高表达的危险因素是H-Ras高表达与肿瘤家族史且二者具有协同作用. 结论 p53和H-Ras高表达是西安地区食管癌重要的生物学标志.

    Molecular epidemiological study on esophageal can┐cer in Xi'an

    WANG An-Hui ZHANG Hong-Yan WANG Yan YAN Ming-Xiao SUN Chang-Sheng LI Liang-Shou HUANG Jiu-Yi CHENG Qing-Shu ZHU Yi-Fang

    1 Department of Epidemiology，Faculty of Preventive Medicine，Fourth Military Medical University，Xi'an710033，China，

    2 Department of Thoracic Surgery，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China

    Keywords:esophageal;neoplasms;epidemiology，molecu-lar;Xi'an

    Abstract:AIM To evaluate the over expression of p53pro-tein and H-Ras in the process of esophageal cancer(EC)in Xi'an city.METHODS Molecular epidemiological case-control study was carried out to study the risk factor of EC in Xi'an ......