【摘要】 目的 探讨人类膀胱癌组织中树突状细胞(dendritic cell，DC)、血管内皮生长因子(VEGF)的表达及其意义。方法 应用免疫组化(S-P)法，检测45例人类膀胱癌组织中DC和VEGF的表达情况。结果 膀胱癌的临床分期和病理分级与DC的浸润程度呈负相关(P<0.05)；与VEGF的表达呈正相关(P<0.05)。DC在癌组织中的表达与VEGF呈负相关(P<0.01)。 结论 DC和VEGF的表达可以作为判断膀胱癌恶性程度和预后的参考指标，VEGF可以抑制DC在肿瘤组织中的浸润，从而导致肿瘤细胞逃脱机体的免疫监视。

    【关键词】 膀胱肿瘤；树突状细胞；血管内皮生长因子

    The expression and significance of dendritic cells and VEGF in bladder cancer

    ZHANG Li-hui， LI Mu-song，LI Yong-gang，et al.

    The 8644 Armed Police Hospital,Hebei 072450,China

    【Abstract】 Objective To study the expression and significance of dendritic cells and vascular endothelial growth factor (VEGF) in human bladder cancer.Methods The expressions of S-100+DC and VEGF in 45 cases of bladder cancer were detected by immunohistochemistry using streptavidin/peroxidase(SP).Results The clinical stage and histological grade of bladder cancer was inversely correlated with the number of S-100+DC(P<0.05)；but positively correlated with the expression of VEGF(P<0.05); The expression of VEGF was significantly lower in samples with highly infiltrating S-100+DC(P<0.01).Conclusion The expression of DC and VEGF could be viewed as a valuable index in judging the malignant degree and prognosis of bladder cancer ......