李瑜元 聂玉强 胡品津 陈湖 王启仪 张振书 胡品津 陈湖(第一军医大学南方医院，广州 510515)；李瑜元 聂玉强 陈湖 王启仪 张振书(广州市第一人民医院,广州 510180) 中国新药杂志 2000 0 9 2


    关键词：十二指肠溃疡；泮托拉唑 期刊 zgxyzz 0 119-120 泮托拉唑专栏 fur -->


    

摘要 目的：了解泮托拉唑治疗十二指肠溃疡的疗效和安全性。方法：82例十二指肠溃疡患者随机分为2组，各41例。分别服泮托拉唑40 mg和奥美拉唑20 mg，qd，疗效均为2周。结果：两组溃疡愈合率分别为75.6%和68.3%，总有效率分别为97.6% 与100%，两组间无显著性差异(P>0.05)；两组腹痛消失时间分别为(3.1±1.5)和(3.2±1.6)d，无显著差别(P>0.05)。结论：2周常规剂量，泮托拉唑可有效地愈合溃疡和缓解症状。

A COMPARISON OFPANTOPRAZOLE VS OMEPRAZOLE

    IN TREATMENT OF DUODENAL ULCERS

Li Yuyuan, Nie Yuqiang,Hu Pinjin, et al.

    (The First Peoples Hospital of Guangzhou, Guangzhou, 510180)

ABSTRACT OBJECTIVE: To compare theeffect and safety of pantopra zole and omeprazole in the treatment of duodenal ulcers.METHODS: Patients with endoscopically confirmed active duodenal ulcer s were randomizedassigned to received pantoprazole 40 mg,qd or omeprazole 20 m g/day for 2 weeks. Theulcers healing were investigated with endoscopy after ce s sation of drugs. Thesymptomatic relief was assessed before、during and after t reatment. RESULTS: After 2weeks, duodenal ulcers healing was found in 75.6% o f the pantoprazole group (31/41) andin 68.3% of omeprazole group (28/41), there is no significant difference (P>0.05). Thepain relief was no significant difference between two group (P>0.05). CONCLUSION: Theduodenal ulcers healing at 2 weeks was similar betwee n pantoprazole and omeprazole.

     KEY WORDS Duodenal ulcer; Pantoprazole

1998年11月～1999年3月 ......

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