崔喆 李黎明 强万明 王建宇 吴明明 虞颂庭 300052 天津医科大学总医院泌尿外科 中华实验外科杂志 1999 0 16 6


    关键词：免疫治疗；红色诺卡氏菌；膀胱癌 期刊 zhsywkzz 0 论 著 fur -->


    

【摘要】 目的 探讨红色诺卡氏菌细胞壁骨架(N-CWS)对膀胱肿瘤的治疗效果及其机理。方法 观察皮下注射N-CWS对小鼠同系移植膀胱癌的抗癌效应和N-CWS对细胞免疫因子的影响。结果 给予N-CWS的小鼠与肿瘤对照组比较肿瘤消退率为41.67%，抑瘤率为96.2%；N-CWS组IL-1、IL-2、IL-6及NK细胞活性和部分T细胞亚群则明显高于肿瘤对照组，但未能达到正常对照组的水平。结论 N-CWS对膀胱癌具有明显的抗癌效应，其机理为通过提高机体的IL-1、IL-2、IL-6水平和NK的活性及部分T细胞亚群，提高机体的抗肿瘤免疫能力。

The inhibitory effects of N-CWS on bladder carcinoma and the immune mechanism in mice

CUI ZHE, LI Liming, QIANG Wanming, et al.

    Department of Urology, The General Hospital of Tianjin Medical University, Tianjin 300052

【Abstract】 Objective To evaluate theeffect and mechanics of Nocardia rubra cell wall skeleton (N-CWS) in the treatment ofbladder carcinoma in mice. Methods After subcutaneous injection of N-CWS, the anti-tumor effects of N-CWS and the influence of N-CWS on IL-1, IL-2, IL-6, Tlymphocyte subgroup and the activity of NK were studied on transplanted bladder carcinoma(BST₇₃₉ ) in syngeneic T₇₃₉ mice. Results Thetumor inhibition rate in the mice treated with N-CWS was 96.2%. The levels of IL-1, IL-2,IL-6 and the activity of NK in the mice treated with N-CWS was higher than those in tumorcontrol mice. Conclusion N-CWS, as an immune promoter, had obviousanti-tumor effects on bladder carcinoma. The mechanism may be that the levels of IL-1,IL-2, IL-6, NK activity and part T lymphocyte subgroups, and human anti-tumorimmunological function are increased by N-CWS.

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