【摘要】 目的 研究脑梗死后的炎症反应，探讨IL-16在脑梗死后炎症反应中的作用。 方法 于入院后第2天及第14天应用ELISA方法测定患者外周血TNF-α、IL-6、IL-16、sVCAM-1和D-Dimer水平。 结果 急性脑梗死组病人发病早期TNF-α、IL-6、IL-16、sVCAM-1和D-Dimer含量明显高于健康对照组，在统计学上差异有显著性，发病2周后TNF-α水平基本恢复正常，其余四个细胞因子虽有明显下降，但仍明显高于正常。 结论 IL-16参与了急性脑梗死后的炎症反应，调节和控制炎症反应将成为治疗脑梗死新的治疗手段。

    【关键词】 脑梗死 炎症反应

    Dynamic observation of IL-16in peripheral blood of the patient with acute cerebral infarction

    Chen Yudan，Chen Tianfeng

    Departmont of Neurology，Beijing Chaoyang Hospital，Capital University of Medical Sciences，Beijing100020.

    【Abstract】 Objective To observe the inflammatory reactions and to investingate the alternations of IL-16in patients after the acute cerebral infarction.Methods Serum TNF-α，IL-6，IL-16，sVCAM-1and plasma D-Dimer concentrations were measured by ELISA method on the2th day and the14th day after the patients had been in hospital.Results The concentrations of TNF-α，IL-6，IL-16，sVCAM-1in serum and D-Dimer in plasma of all the patients suffered from acute cerebral infarction were higher than the normal control.After two weeks，the level of the four cytokines dropped a lot ......